| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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| Ligand | BDBM15349 |
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| Substrate/Competitor | BDBM15346 |
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| Meas. Tech. | DHODH Inhibition Assay |
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| IC50 | 105000±n/a nM |
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| Citation |  Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
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| Synonyms: | DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN |
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| Type: | Enzyme |
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| Mol. Mass.: | 39678.95 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli. |
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| Residue: | 366 |
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| Sequence: | ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
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| BDBM15349 |
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| BDBM15346 |
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| Name | BDBM15349 |
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| Synonyms: | Asinex compound no. 4 | N-(3-bromophenyl)-2-methyl-3-nitrobenzamide |
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| Type | Small organic molecule |
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| Emp. Form. | C14H11BrN2O3 |
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| Mol. Mass. | 335.153 |
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| SMILES | Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(Br)c1 |
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| Structure | 
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