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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
LigandBDBM14711
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50 200000±n/a nM
Citation Baldwin, JMichnoff, CHMalmquist, NAWhite, JRoth, MGRathod, PKPhillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395]
Synonyms:DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN
Type:Enzyme
Mol. Mass.:39678.95
Organism:Homo sapiens (Human)
Description:Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli.
Residue:366
Sequence:
ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
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BDBM14711
BDBM15346
NameBDBM14711
Synonyms:Asinex compound no. 6 | N-(3,5-Dichlorophenyl)-2-methyl-3-nitrobenzamide | benzamide compound 3
TypeSmall organic molecule
Emp. Form.C14H10Cl2N2O3
Mol. Mass.325.147
SMILESCc1c(cccc1[N+]([O-])=O)C(=O)Nc1cc(Cl)cc(Cl)c1
Structure
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