| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
|---|
| Ligand | BDBM15352 |
|---|
| Substrate/Competitor | BDBM15346 |
|---|
| Meas. Tech. | DHODH Inhibition Assay |
|---|
| IC50 | 200000±n/a nM |
|---|
| Citation |  Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial [30-395] |
|---|
| Synonyms: | DHODH | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | PYRD_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 39678.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Recombinant human DHODH (amino acids 30 to 395) was cloned and expressed in E. coli. |
|---|
| Residue: | 366 |
|---|
| Sequence: | ATGDERFYAEHLMPTLQGLLDPESAHRLAVRFTSLGLLPRARFQDSDMLEVRVLGHKFRN
PVGIAAGFDKHGEAVDGLYKMGFGFVEIGSVTPKPQEGNPRPRVFRLPEDQAVINRYGFN
SHGLSVVEHRLRARQQKQAKLTEDGLPLGVNLGKNKTSVDAAEDYAEGVRVLGPLADYLV
VNVSSPNTAGLRSLQGKAELRRLLTKVLQERDGLRRVHRPAVLVKIAPDLTSQDKEDIAS
VVKELGIDGLIVTNTTVSRPAGLQGALRSETGGLSGKPLRDLSTQTIREMYALTQGRVPI
IGVGGVSSGQDALEKIRAGASLVQLYTALTFWGPPVVGKVKRELEALLKEQGFGGVTDAI
GADHRR
|
|
|
|---|
| BDBM15352 |
|---|
| BDBM15346 |
|---|
| Name | BDBM15352 |
|---|
| Synonyms: | ChemBridge compound no. 7 | N-(3,4-difluorophenyl)-2-methyl-3-nitrobenzamide |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C14H10F2N2O3 |
|---|
| Mol. Mass. | 292.2376 |
|---|
| SMILES | Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(F)c1 |
|---|
| Structure | 
|
|---|
Search and Browse
