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TargetDihydroorotate Dehydrogenase (DHODH) Mutant (R265A)
LigandBDBM15349
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50 1200±n/a nM
Citation Baldwin JMichnoff CHMalmquist NAWhite JRoth MGRathod PKPhillips MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem 280:21847-53 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A)
Name:Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A)
Synonyms:DHOdehase | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | pfR265A
Type:Enzyme
Mol. Mass.:65495.77
Organism:Plasmodium falciparum
Description:n/a
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFADVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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  Blast E-value cutoff:
BDBM15349
BDBM15346
NameBDBM15349
Synonyms:Asinex compound no. 4 | N-(3-bromophenyl)-2-methyl-3-nitrobenzamide
TypeSmall organic molecule
Emp. Form.C14H11BrN2O3
Mol. Mass.335.153
SMILESCc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc(Br)c1
Structure
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