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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
LigandBDBM15350
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50 500±n/a nM
Citation Baldwin, JMichnoff, CHMalmquist, NAWhite, JRoth, MGRathod, PKPhillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | pfR265A
Type:Enzyme
Mol. Mass.:65495.77
Organism:Plasmodium falciparum
Description:Q54A96[R265A]
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFADVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM15350
BDBM15346
NameBDBM15350
Synonyms:ChemBridge compound no. 5 | N-(3-chloro-4-fluorophenyl)-2-methyl-3-nitrobenzamide
TypeSmall organic molecule
Emp. Form.C14H10ClFN2O3
Mol. Mass.308.692
SMILESCc1c(cccc1[N+]([O-])=O)C(=O)Nc1ccc(F)c(Cl)c1
Structure
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