Ki Summary

Reaction Details

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Target

Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]

Ligand

BDBM15353

Substrate/Competitor

BDBM15346

Meas. Tech.

DHODH Inhibition Assay

IC50

480±n/a nM

Citation

Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]

Name:

Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]

Synonyms:

DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | pfR265A

Type:

Enzyme

Mol. Mass.:

65495.77

Organism:

Plasmodium falciparum

Description:

Q54A96[R265A]

Residue:

569

Sequence:

MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFADVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS

BDBM15353

BDBM15346

Name

BDBM15353

Synonyms:

2-methyl-N-(naphthalen-1-yl)-3-nitrobenzamide | ChemBridge compound no. 8

Type

Small organic molecule

Emp. Form.

C18H14N2O3

Mol. Mass.

306.3154

SMILES

Cc1c(cccc1[N+]([O-])=O)C(=O)Nc1cccc2ccccc12

Structure