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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
LigandBDBM15358
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50 2000±n/a nM
Citation Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [R265A]
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (R265A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase | pfR265A
Type:Enzyme
Mol. Mass.:65495.77
Organism:Plasmodium falciparum
Description:Q54A96[R265A]
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICHDLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFADVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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  Blast E-value cutoff:
BDBM15358
BDBM15346
NameBDBM15358
Synonyms:3-(4-chlorophenyl)-1-quinolin-8-ylurea | Asinex compound no. 13
TypeSmall organic molecule
Emp. Form.C16H12ClN3O
Mol. Mass.297.739
SMILESClc1ccc(NC(=O)Nc2cccc3cccnc23)cc1
Structure
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