Reaction Details |
| Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A] |
---|
Ligand | BDBM15348 |
---|
Substrate/Competitor | BDBM15346 |
---|
Meas. Tech. | DHODH Inhibition Assay |
---|
IC50 | 210000±n/a nM |
---|
Citation | Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A] |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A] |
Synonyms: | DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (H185A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase |
Type: | Enzyme |
Mol. Mass.: | 65515.32 |
Organism: | Plasmodium falciparum |
Description: | Q54A96[H185A] |
Residue: | 569 |
Sequence: | MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICADLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
|
|
|
BDBM15348 |
---|
BDBM15346 |
---|
Name | BDBM15348 |
Synonyms: | ChemBridge compound no. 3 | N-(2-fluorophenyl)naphthalene-2-carboxamide |
Type | Small organic molecule |
Emp. Form. | C17H12FNO |
Mol. Mass. | 265.2817 |
SMILES | Fc1ccccc1NC(=O)c1ccc2ccccc2c1 |
Structure |
|