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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [H185A]
LigandBDBM15348
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50 210000±n/a nM
Citation Baldwin, JMichnoff, CHMalmquist, NAWhite, JRoth, MGRathod, PKPhillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A]
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (H185A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:65515.32
Organism:Plasmodium falciparum
Description:Q54A96[H185A]
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICADLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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BDBM15348
BDBM15346
NameBDBM15348
Synonyms:ChemBridge compound no. 3 | N-(2-fluorophenyl)naphthalene-2-carboxamide
TypeSmall organic molecule
Emp. Form.C17H12FNO
Mol. Mass.265.2817
SMILESFc1ccccc1NC(=O)c1ccc2ccccc2c1
Structure
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