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TargetDihydroorotate dehydrogenase (quinone), mitochondrial [H185A]
LigandBDBM15356
Substrate/CompetitorBDBM15346
Meas. Tech.DHODH Inhibition Assay
IC50>200000±n/a nM
Citation Baldwin, J; Michnoff, CH; Malmquist, NA; White, J; Roth, MG; Rathod, PK; Phillips, MA High-throughput screening for potent and selective inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase. J Biol Chem280:21847-53 (2005) [PubMed]  Article
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Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A]
Name:Dihydroorotate dehydrogenase (quinone), mitochondrial [H185A]
Synonyms:DHOdehase | Dihydroorotate Dehydrogenase (DHODH) Mutant (H185A) | Dihydroorotate dehydrogenase homolog | Dihydroorotate oxidase
Type:Enzyme
Mol. Mass.:65515.32
Organism:Plasmodium falciparum
Description:Q54A96[H185A]
Residue:569
Sequence:
MISKLKPQFMFLPKKHILSYCRKDVLNLFEQKFYYTSKRKESNNMKNESLLRLINYNRYY
NKIDSNNYYNGGKILSNDRQYIYSPLCEYKKKINDISSYVSVPFKINIRNLGTSNFVNNK
KDVLDNDYIYENIKKEKSKHKKIIFLLFVSLFGLYGFFESYNPEFFLYDIFLKFCLKYID
GEICADLFLLLGKYNILPYDTSNDSIYACTNIKHLDFINPFGVAAGFDKNGVCIDSILKL
GFSFIEIGTITPRGQTGNAKPRIFRDVESRSIINSCGFNNMGCDKVTENLILFRKRQEED
KLLSKHIVGVSIGKNKDTVNIVDDLKYCINKIGRYADYIAINVSSPNTPGLRDNQEAGKL
KNIILSVKEEIDNLEKNNIMNDESTYNEDNKIVEKKNNFNKNNSHMMKDAKDNFLWFNTT
KKKPLVFVKLAPDLNQEQKKEIADVLLETNIDGMIISNTTTQINDIKSFENKKGGVSGAK
LKDISTKFICEMYNYTNKQIPIIASGGIFSGLDALEKIEAGASVCQLYSCLVFNGMKSAV
QIKRELNHLLYQRGYYNLKEAIGRKHSKS
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  Blast E-value cutoff:
BDBM15356
BDBM15346
NameBDBM15356
Synonyms:1-naphthalen-1-yl-3-[2-(trifluoromethyl)phenyl]urea | SPECS compound no. 11
TypeSmall organic molecule
Emp. Form.C18H13F3N2O
Mol. Mass.330.3038
SMILESFC(F)(F)c1ccccc1NC(=O)Nc1cccc2ccccc12
Structure
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