Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Heat shock protein HSP 90-beta | ||
Ligand | BDBM15404 | ||
Substrate/Competitor | BDBM15360 | ||
Meas. Tech. | Fluorescence Polarization (FP) Assay | ||
pH | 7.4±n/a | ||
Temperature | 295.15±n/a K | ||
IC50 | 2200±n/a nM | ||
Citation | Barril, X; Brough, P; Drysdale, M; Hubbard, RE; Massey, A; Surgenor, A; Wright, L Structure-based discovery of a new class of Hsp90 inhibitors. Bioorg Med Chem Lett15:5187-91 (2005) [PubMed] Article | ||
More Info.: | Get all data from this article, Solution Info, Assay Method | ||
Heat shock protein HSP 90-beta | |||
Name: | Heat shock protein HSP 90-beta | ||
Synonyms: | HS90B_HUMAN | HSP 84 | HSP 90 | HSP90AB1 | HSP90B | HSPC2 | HSPCB | Heat Shock Protein 90 (Hsp90) | Heat shock protein HSP 90 (Hsp90) | ||
Type: | Molecular Chaperone | ||
Mol. Mass.: | 83229.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P08238 | ||
Residue: | 724 | ||
Sequence: |
| ||
BDBM15404 | |||
BDBM15360 | |||
Name | BDBM15404 | ||
Synonyms: | 4-chloro-N-[4-hydroxy-3-(2-hydroxynaphthalen-1-yl)phenyl]benzene-1-sulfonamide | naphthol compound 7 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H16ClNO4S | ||
Mol. Mass. | 425.885 | ||
SMILES | Oc1ccc(NS(=O)(=O)c2ccc(Cl)cc2)cc1-c1c(O)ccc2ccccc12 |(-4.43,.59,;-4.43,2.13,;-5.77,2.9,;-5.77,4.45,;-4.43,5.22,;-4.43,6.76,;-3.1,7.53,;-3.87,8.86,;-2.33,6.19,;-1.77,8.3,;-1.77,9.84,;-.43,10.61,;.9,9.84,;2.23,10.61,;.9,8.3,;-.43,7.53,;-3.1,4.45,;-3.1,2.9,;-1.77,2.13,;-1.77,.59,;-3.1,-.18,;-.43,-.18,;.9,.59,;.9,2.13,;2.23,2.91,;2.23,4.45,;.9,5.22,;-.43,4.45,;-.43,2.91,)| | ||
Structure |