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TargetE3 ubiquitin-protein ligase Mdm2 [17-125]
LigandBDBM227669
Substrate/Competitorn/a
Meas. Tech.FRET Assay
Temperature298.15±n/a K
IC50 0.359±n/a nM
Commentsextracted
Citation Cammarano, CMChristopher, MPDinsmore, CDoll, RJFradera Llinas, FXLi, CMachacek, MMartinez, MNair, LGPan, WReutershan, MHShizuka, MSteinhuebel, DPSun, BThompson, CFTrotter, BWWang, YYang, LBogen, SLVoss, MEPanda, JKurissery, AT 2,6,7,8 substituted purines as HDM2 inhibitors US Patent US9540377 Publication Date 1/10/2017
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E3 ubiquitin-protein ligase Mdm2 [17-125]
Name:E3 ubiquitin-protein ligase Mdm2 [17-125]
Synonyms:Double minute 2 protein | E3 ubiquitin-protein ligase Mdm2 | MDM2 | MDM2_HUMAN | p53-binding protein Mdm2
Type:Enzyme Catalytic Domain
Mol. Mass.:12522.24
Organism:Homo sapiens (Human)
Description:Residue 17 to 125
Residue:109
Sequence:
SQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVY
CSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQQESSDSGTSVSEN
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BDBM227669
n/a
NameBDBM227669
Synonyms:5-{6-(5-chloropyridin-3- yl)-8-[1-fluoro-1-(3- fluoropyridin-2-yl)ethyl]- 7-[(trans-4- methylcyclohexyl)methyl]- 7h-purin-2-yl}-1,3,4- oxadiazol-2(3h)-one (enantiomer 1) | US9540377, 23.84 | US9540377, 23.85
TypeSmall organic molecule
Emp. Form.C27H25ClF2N8O2
Mol. Mass.566.99
SMILESC[C@H]1CC[C@H](Cn2c(nc3nc(nc(-c4cncc(Cl)c4)c23)-c2n[nH]c(=O)o2)C(C)(F)c2ncccc2F)CC1 |r,wU:4.4,wD:1.0,(7.09,-3.69,;5.6,-3.29,;5.21,-1.81,;3.72,-1.41,;2.63,-2.5,;1.14,-2.1,;.74,-.61,;1.65,.64,;.74,1.88,;-.72,1.41,;-2.05,2.18,;-3.39,1.41,;-3.39,-.13,;-2.05,-.9,;-2.05,-2.44,;-.72,-3.21,;-.72,-4.75,;-2.05,-5.52,;-3.39,-4.75,;-4.72,-5.52,;-3.39,-3.21,;-.72,-.13,;-4.72,2.18,;-6.19,1.7,;-7.09,2.95,;-6.19,4.19,;-6.96,5.52,;-4.72,3.72,;3.19,.64,;4.73,.64,;3.96,-.7,;3.96,1.97,;5.5,1.97,;6.27,3.3,;5.5,4.64,;3.96,4.64,;3.19,3.3,;1.65,3.3,;3.03,-3.98,;4.52,-4.38,)|
Structure
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