Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetInterleukin-1 receptor-associated kinase 1 [194-712]
LigandBDBM347810
Substrate/Competitorn/a
Meas. Tech.Enzymatic Assay
IC50 550±n/a nM
Citation Jorand-Lebrun, CJones, RWon, ACNguyen, NJohnson, TLDeselm, LCPanda, K Heteroaryl compounds as IRAK inhibitors and uses thereof US Patent US9790221 Publication Date 10/17/2017
More Info.:Get all data from this article,  Assay Method
 
Interleukin-1 receptor-associated kinase 1 [194-712]
Name:Interleukin-1 receptor-associated kinase 1 [194-712]
Synonyms:IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)
Type:Enzyme Catalytic Domain
Mol. Mass.:55943.99
Organism:Homo sapiens (Human)
Description:aa 194-712
Residue:519
Sequence:
RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM347810
n/a
NameBDBM347810
Synonyms:US9790221, Compound 16
TypeSmall organic molecule
Emp. Form.C24H26N8O2S
Mol. Mass.490.581
SMILESCC(C)Nc1nc(ncc1-c1nnc(s1)C(=O)N1CC[C@@H](O)C1)-c1cccc(c1)-c1cnn(C)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: