Ki Summary

Reaction Details

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Target

Interleukin-1 receptor-associated kinase 1 [194-712]

Ligand

BDBM348001

Substrate/Competitor

n/a

Meas. Tech.

Enzymatic Assay

IC50

<100±n/a nM

Citation

Jorand-Lebrun, C; Jones, R; Won, AC; Nguyen, N; Johnson, TL; Deselm, LC; Panda, K Heteroaryl compounds as IRAK inhibitors and uses thereof US Patent US9790221 Publication Date 10/17/2017

More Info.:

Get all data from this article, Assay Method

Interleukin-1 receptor-associated kinase 1 [194-712]

Name:

Interleukin-1 receptor-associated kinase 1 [194-712]

Synonyms:

IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1)

Type:

Enzyme Catalytic Domain

Mol. Mass.:

55943.99

Organism:

Homo sapiens (Human)

Description:

aa 194-712

Residue:

519

Sequence:

RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS

BDBM348001

n/a

Name

BDBM348001

Synonyms:

US9790221, Compound 209

Type

Small organic molecule

Emp. Form.

C26H30N8O2S2

Mol. Mass.

550.699

SMILES

Cc1nnc(s1)-c1cnc(nc1NC1CCC(CC1)NS(=O)(=O)C1CC1)-c1cccc(c1)-c1cnn(C)c1 |(-6.88,-8.14,;-6.11,-6.81,;-4.57,-6.81,;-4.09,-5.35,;-5.33,-4.44,;-6.58,-5.34,;-5.33,-2.9,;-6.66,-2.13,;-6.66,-.59,;-5.32,.18,;-3.99,-.59,;-3.99,-2.13,;-2.66,-2.91,;-1.33,-2.14,;0,-2.92,;1.34,-2.14,;1.34,-.6,;0,.18,;-1.33,-.6,;2.68,.17,;4.01,-.6,;4.01,-2.14,;5.34,.17,;5.34,-1.37,;6.11,-2.71,;6.88,-1.37,;-5.32,1.72,;-6.65,2.49,;-6.65,4.03,;-5.31,4.8,;-3.98,4.03,;-3.98,2.49,;-2.64,4.79,;-1.18,4.31,;-.27,5.56,;-1.18,6.81,;-.41,8.14,;-2.64,6.33,)|

Structure