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TargetMonoamine Oxidase Type A (MAO-A)
LigandBDBM15604
Substrate/CompetitorBDBM10990
Meas. Tech.MAO Activity Assay
Ki 1.7±n/a nM
Citation La Regina GSilvestri RArtico MLavecchia ANovellino EBefani OTurini PAgostinelli E New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem 50:922-31 (2007) [PubMed]  Article
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Monoamine Oxidase Type A (MAO-A)
Name:Monoamine oxidase
Synonyms:Amine oxidase [flavin-containing] A | MAO-A | Monoamine oxidase A | Monoamine oxidase type A
Type:PROTEIN
Mol. Mass.:59764.63
Organism:Bos taurus
Description:ChEMBL_1501477
Residue:527
Sequence:
MESLQKTSDAGQMFDVVVIGGGISGLSAAKLLAEHEVNVLVLEARERVGGRTYTVRNEHV
DYVDVGGAYVGPTQNRILRLSKQLGLETYKVNVNERLVHYVKGKTYPFRGAFPPVWNPIA
YLDYNNLWRTMDNMGKEIPADAPWEAPHAVEWDKMTMKDLIEKICWTKTARQFASLFVNI
NVTSEPHEVSALWFLWYVKQCGGTTRIFSITNGGQERKFVGGSGQVSERIMQLLGDRVKL
RSPVTYVDQSSENITVETLNRELYECRYVISAIPPTLTAKIHFRPELPSERNQLIQRLPM
GAVIKCMMYYKEAFWKKKDYCGCMIIEDEEAPISITLDDTKPDGSLPAIMGFILARKADR
LAKVHKDIRKRKICELYAKVLGSQEALHPVHYEEKNWCQEQYSGGCYTAYFPPGIMTQYG
RVIRQPVGRIYFAGTETATQWSGYMEGAVEAGERAAREVLNALGKLSAKDIWIQEPEAED
VPAVEITPSFWERNLPSVSGLLKIVGFSTSITALWFVMYRFRLLSRS
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  Blast E-value cutoff:
BDBM15604
BDBM10990
NameBDBM15604
Synonyms:(R)-N-(alpha-Cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide | N-[(1R)-1-cyclohexylethyl]-N-methyl-1H-pyrrole-2-carboxamide | pyrrole inhibitor 29
TypeSmall organic molecule
Emp. Form.C14H22N2O
Mol. Mass.234.3373
SMILESC[C@H](C1CCCCC1)N(C)C(=O)c1ccc[nH]1 |r|
Structure
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