Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetAmine oxidase [flavin-containing] B
LigandBDBM15604
Substrate/CompetitorBDBM10990
Meas. Tech.MAO Activity Assay
Ki 30±n/a nM
Citation La Regina, G; Silvestri, R; Artico, M; Lavecchia, A; Novellino, E; Befani, O; Turini, P; Agostinelli, E New pyrrole inhibitors of monoamine oxidase: synthesis, biological evaluation, and structural determinants of MAO-A and MAO-B selectivity. J Med Chem50:922-31 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Amine oxidase [flavin-containing] B
Name:Amine oxidase [flavin-containing] B
Synonyms:AOFB_BOVIN | Amine oxidase [flavin-containing] B | MAO-B | MAOB | Monoamine Oxidase Type B (MAO-B) | Monoamine oxidase | Monoamine oxidase B | Monoamine oxidase type B
Type:PROTEIN
Mol. Mass.:58428.94
Organism:Bos taurus
Description:ChEMBL_1501478
Residue:520
Sequence:
MSSKCDVVVVGGGISGMAAAKLLHDSGLNVIVLEARDRVGGRTYTLRNQKVKYVDLGGSY
VGPTQNHILRLSKELGLETYKVNEVERLIHHTKGKSYPFRGSFPSVWNPITYLDHNNLWR
TMDDMGREIPSDAPWKAPLAEQWDLMTMKELLDKICWTESSKQLAILFVNLCVTAEIHEV
SALWFLWYVKQCGGTTRIFSTSNGGQERKFVGGSGQVSERIMDLLGDRVKLERPVIHIDQ
TGENVLVETLNHELYEAKYVISAVPPVLGMKIHFNPPLPMMRNQLITRVPLGSVIKSIVY
YKEPFWRNMDYCGSMIIEGEEAPVAYALDDTKPDGSYPAIIGFILAHKARKLARLTKEER
LKKLCDLYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTSYFPPGIMTQYGRVLRQPVGR
IYFAGTETATHWSGYMEGAVEAGERAAREILHAMGKIPEDEIWLPEPESVDVPAKPITTT
FLQRHLPSVPGLLKLIGLTTIFSATALGFLAHKRGLLVRI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM15604
BDBM10990
NameBDBM15604
Synonyms:(R)-N-(alpha-Cyclohexylethyl),N-methyl-1H-pyrrole-2-carboxamide | N-[(1R)-1-cyclohexylethyl]-N-methyl-1H-pyrrole-2-carboxamide | pyrrole inhibitor 29
TypeSmall organic molecule
Emp. Form.C14H22N2O
Mol. Mass.234.3373
SMILESC[C@H](C1CCCCC1)N(C)C(=O)c1ccc[nH]1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: