Reaction Details |
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Target | Chitotriosidase-1 |
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Ligand | BDBM349960 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Human CHIT1 Activity Assay |
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IC50 | <100±n/a nM |
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Citation | Mazur, M; Koralewski, R; Borek, B; Olejniczak, S; Czestkowski, WJ; Piotrowicz, MC; Olczak, JP; Golebiowski, AA; Bartoszewicz, A; Maziarz, E; Kowalski, M Substituted amino triazoles useful as human chitinase inhibitors US Patent US10208020 Publication Date 2/19/2019 |
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More Info.: | Get all data from this article, Assay Method |
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Chitotriosidase-1 |
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Name: | Chitotriosidase-1 |
Synonyms: | CHIT1 | CHIT1_HUMAN | Chitinase 1 | Chitinase-1 | Chitotriosidase | Chitotriosidase-1 | Chitotriosidase-1 (CHIT1) |
Type: | Enzyme |
Mol. Mass.: | 51682.25 |
Organism: | Homo sapiens (Human) |
Description: | Q13231 |
Residue: | 466 |
Sequence: | MVRSVAWAGFMVLLMIPWGSAAKLVCYFTNWAQYRQGEARFLPKDLDPSLCTHLIYAFAG
MTNHQLSTTEWNDETLYQEFNGLKKMNPKLKTLLAIGGWNFGTQKFTDMVATANNRQTFV
NSAIRFLRKYSFDGLDLDWEYPGSQGSPAVDKERFTTLVQDLANAFQQEAQTSGKERLLL
SAAVPAGQTYVDAGYEVDKIAQNLDFVNLMAYDFHGSWEKVTGHNSPLYKRQEESGAAAS
LNVDAAVQQWLQKGTPASKLILGMPTYGRSFTLASSSDTRVGAPATGSGTPGPFTKEGGM
LAYYEVCSWKGATKQRIQDQKVPYIFRDNQWVGFDDVESFKTKVSYLKQKGLGGAMVWAL
DLDDFAGFSCNQGRYPLIQTLRQELSLPYLPSGTPELEVPKPGQPSEPEHGPSPGQDTFC
QGKADGLYPNPRERSSFYSCAAGRLFQQSCPTGLVFSNSCKCCTWN
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BDBM349960 |
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n/a |
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Name | BDBM349960 |
Synonyms: | (3R,5S)-1-(1-(5-amino-1H-1,2,4-triazol-3-yl)piperidin-4-yl)-5-(4-chlorobenzyl)pyrrolidin-3-ol | US10208020, Example 50 | US10538508, Example 50 | US9944624, Ex. 50 |
Type | Small organic molecule |
Emp. Form. | C18H25ClN6O |
Mol. Mass. | 376.884 |
SMILES | Nc1nc(n[nH]1)N1CCC(CC1)N1C[C@H](O)C[C@@H]1Cc1ccc(Cl)cc1 |r| |
Structure |
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