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TargetTyrosine-protein phosphatase non-receptor type 1 [1-298]
LigandBDBM15813
Substrate/CompetitorBDBM13466
Meas. Tech.PTP1B and TCPTP Inhibition Assay
pH7.5±n/a
Temperature295.15±n/a K
Ki 250±100 nM
Citation Xin, ZOost, TKAbad-Zapatero, CHajduk, PJPei, ZSzczepankiewicz, BGHutchins, CWBallaron, SJStashko, MALubben, TTrevillyan, JMJirousek, MRLiu, G Potent, selective inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett13:1887-90 (2003) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Name:Tyrosine-protein phosphatase non-receptor type 1 [1-298]
Synonyms:PTN1_HUMAN | PTP-1B | PTP1B | PTPN1 | PTPase 1B | Protein-Tyrosine Phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase, non-receptor type 1
Type:Enzyme
Mol. Mass.:34670.65
Organism:Homo sapiens (Human)
Description:The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.
Residue:298
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED
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BDBM15813
BDBM13466
NameBDBM15813
Synonyms:1:1 mixture of diastereomers | 2-[(4-{2-[(4-{[(S)-carboxy(cyclohexyl)methyl]carbamoyl}butyl)carbamoyl]-2-acetamidoethyl}-2-ethylphenyl)amidoformic acid]benzoic acid | oxalyl-aryl-amino benzoic acid-based inhibitor 13
TypeSmall organic molecule
Emp. Form.C35H44N4O10
Mol. Mass.680.7447
SMILESCCc1cc(CC(NC(C)=O)C(=O)NCCCCC(=O)N[C@@H](C2CCCCC2)C(O)=O)ccc1N(C(=O)C(O)=O)c1ccccc1C(O)=O |r|
Structure
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