Ki Summary

Reaction Details

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Target

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Ligand

BDBM15817

Substrate/Competitor

BDBM13466

Meas. Tech.

PTP1B and TCPTP Inhibition Assay

7.5±n/a

Temperature

295.15±n/a K

120±70 nM

Citation

Xin, Z; Oost, TK; Abad-Zapatero, C; Hajduk, PJ; Pei, Z; Szczepankiewicz, BG; Hutchins, CW; Ballaron, SJ; Stashko, MA; Lubben, T; Trevillyan, JM; Jirousek, MR; Liu, G Potent, selective inhibitors of protein tyrosine phosphatase 1B. Bioorg Med Chem Lett13:1887-90 (2003) [PubMed] Article

More Info.:

Get all data from this article, Solution Info, Assay Method

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Name:

Tyrosine-protein phosphatase non-receptor type 1 [1-298]

Synonyms:

Type:

Enzyme

Mol. Mass.:

34670.65

Organism:

Homo sapiens (Human)

Description:

The catalytic domain of PTP 1B (residues 1-298) was expressed and purified from E. coli.

Residue:

298

Sequence:

MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLH
QEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLK
CAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWP
DFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKD
PSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHED

BDBM15817

BDBM13466

Name

BDBM15817

Synonyms:

1:1 mixture of diastereomers | 2-[(4-{2-[(4-{[(1S)-1-carboxypentyl]carbamoyl}butyl)carbamoyl]-2-acetamidoethyl}-2-ethylphenyl)amidoformic acid]benzoic acid | oxalyl-aryl-amino benzoic acid-based inhibitor 17

Type

Small organic molecule

Emp. Form.

C33H42N4O10

Mol. Mass.

654.7074

SMILES

CCCC[C@H](NC(=O)CCCCNC(=O)C(Cc1ccc(N(C(=O)C(O)=O)c2ccccc2C(O)=O)c(CC)c1)NC(C)=O)C(O)=O |r|

Structure