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TargetCDK8/Cyclin C
LigandBDBM350228
Substrate/Competitorn/a
Meas. Tech.CDK8/Cyclin C Binding Assay
IC50 14.4±n/a nM
Citation Pastor Fernández JMartínez González SBlanco-Aparicio CHernández Higueras AIGómez De La Oliva CARivero Buceta VRiesco Fagundo RC Condensed tricyclic compounds as protein kinase inhibitors US Patent  US10208056 Publication Date 2/19/2019
More Info.:Get all data from this article,  Assay Method
 
CDK8/Cyclin C
Name:CDK8/Cyclin C
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1562017
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 8
Synonyms:CDK8 | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35
Type:Serine/threonine-protein kinase
Mol. Mass.:53300.21
Organism:Homo sapiens (Human)
Description:P49336
Residue:464
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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Component 2
Name:Cyclin-C
Synonyms:CCNC | Cyclin C | SRB11 homolog | hSRB11
Type:PROTEIN
Mol. Mass.:33244.88
Organism:Homo sapiens (Human)
Description:ChEMBL_107900
Residue:283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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BDBM350228
n/a
NameBDBM350228
Synonyms:US10208056, Compound 58
TypeSmall organic molecule
Emp. Form.C12H11N3O2
Mol. Mass.229.2346
SMILESCC1Oc2cnccc2-c2[nH]c(cc12)C(N)=O
Structure
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