Reaction Details | |||
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Target | Cyclin-C/Cyclin-dependent kinase 8 | ||
Ligand | BDBM350241 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | CDK8/Cyclin C Binding Assay | ||
IC50 | 3.23±n/a nM | ||
Citation | Pastor Fernández, J; Martínez González, S; Blanco-Aparicio, C; Hernández Higueras, AI; Gómez De La Oliva, CA; Rivero Buceta, V; Riesco Fagundo, RC Condensed tricyclic compounds as protein kinase inhibitors US Patent US10208056 Publication Date 2/19/2019 | ||
More Info.: | Get all data from this article, Assay Method | ||
Cyclin-C/Cyclin-dependent kinase 8 | |||
Name: | Cyclin-C/Cyclin-dependent kinase 8 | ||
Synonyms: | CDK8/Cyclin C | ||
Type: | n/a | ||
Mol. Mass.: | n/a | ||
Description: | ASSAY_ID of ChEMBL is 1562017 | ||
Components: | This complex has 2 components. | ||
Component 1 | |||
Name: | Cyclin-dependent kinase 8 | ||
Synonyms: | CDK8 | CDK8_HUMAN | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35 | ||
Type: | Serine/threonine-protein kinase | ||
Mol. Mass.: | 53300.21 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P49336 | ||
Residue: | 464 | ||
Sequence: |
| ||
Component 2 | |||
Name: | Cyclin-C | ||
Synonyms: | CCNC | CCNC_HUMAN | Cyclin C | SRB11 homolog | hSRB11 | ||
Type: | PROTEIN | ||
Mol. Mass.: | 33244.88 | ||
Organism: | Homo sapiens (Human) | ||
Description: | ChEMBL_107900 | ||
Residue: | 283 | ||
Sequence: |
| ||
BDBM350241 | |||
n/a | |||
Name | BDBM350241 | ||
Synonyms: | US10208056, Compound 68 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H23N3O3 | ||
Mol. Mass. | 377.4363 | ||
SMILES | CCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC |(-1.84,4.02,;-2.24,2.53,;-1.15,1.44,;.38,1.6,;1.15,2.93,;2.69,2.93,;.38,4.27,;1.01,.19,;-.14,-.84,;-1.47,-.07,;-2.8,-.84,;-4.14,-.07,;-5.47,-.84,;-5.47,-2.38,;-4.14,-3.15,;-2.8,-2.38,;-1.47,-3.15,;-.14,-2.38,;-.14,-3.92,;1.2,-3.15,;2.5,-.2,;3.58,.88,;5.07,.49,;5.47,-1,;4.38,-2.09,;2.89,-1.69,;1.81,-2.78,;2.2,-4.27,)| | ||
Structure |