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TargetCDK8/Cyclin C
LigandBDBM350241
Substrate/Competitorn/a
Meas. Tech.CDK8/Cyclin C Binding Assay
IC50 3.23±n/a nM
Citation Pastor Fernández JMartínez González SBlanco-Aparicio CHernández Higueras AIGómez De La Oliva CARivero Buceta VRiesco Fagundo RC Condensed tricyclic compounds as protein kinase inhibitors US Patent  US10208056 Publication Date 2/19/2019  Article
More Info.:Get all data from this article,  Assay Method
 
CDK8/Cyclin C
Name:CDK8/Cyclin C
Synonyms:n/a
Type:n/a
Mol. Mass.:n/a
Description:ASSAY_ID of ChEMBL is 1562017
Components:This complex has 2 components.
Component 1
Name:Cyclin-dependent kinase 8
Synonyms:CDK8 | Cell division protein kinase 8 | Cyclin-Dependent Kinase 8 (CDK8) | Mediator complex subunit CDK8 | Mediator of RNA polymerase II transcription subunit CDK8 | Protein kinase K35
Type:Serine/threonine-protein kinase
Mol. Mass.:53300.21
Organism:Homo sapiens (Human)
Description:P49336
Residue:464
Sequence:
MDYDFKVKLSSERERVEDLFEYEGCKVGRGTYGHVYKAKRKDGKDDKDYALKQIEGTGIS
MSACREIALLRELKHPNVISLQKVFLSHADRKVWLLFDYAEHDLWHIIKFHRASKANKKP
VQLPRGMVKSLLYQILDGIHYLHANWVLHRDLKPANILVMGEGPERGRVKIADMGFARLF
NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQED
IKTSNPYHHDQLDRIFNVMGFPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKYMEKH
KVKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYFLEDPLPTSDVFAGCQIPYPKREFLT
EEEPDDKGDKKNQQQQQGNNHTNGTGHPGNQDSSHTQGPPLKKVRVVPPTTTSGGLIMTS
DYQRSNPHAAYPNPGPSTSQPQSSMGYSATSQQPPQYSHQTHRY
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Component 2
Name:Cyclin-C
Synonyms:CCNC | Cyclin C | SRB11 homolog | hSRB11
Type:PROTEIN
Mol. Mass.:33244.88
Organism:Homo sapiens (Human)
Description:ChEMBL_107900
Residue:283
Sequence:
MAGNFWQSSHYLQWILDKQDLLKERQKDLKFLSEEEYWKLQIFFTNVIQALGEHLKLRQQ
VIATATVYFKRFYARYSLKSIDPVLMAPTCVFLASKVEEFGVVSNTRLIAAATSVLKTRF
SYAFPKEFPYRMNHILECEFYLLELMDCCLIVYHPYRPLLQYVQDMGQEDMLLPLAWRIV
NDTYRTDLCLLYPPFMIALACLHVACVVQQKDARQWFAELSVDMEKILEIIRVILKLYEQ
WKNFDERKEMATILSKMPKPKPPPNSEGEQGPNGSQNSSYSQS
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BDBM350241
n/a
NameBDBM350241
Synonyms:US10208056, Compound 68
TypeSmall organic molecule
Emp. Form.C22H23N3O3
Mol. Mass.377.4363
SMILESCCn1c(C(N)=O)c(c2c1-c1ccncc1OC2(C)C)-c1ccccc1OC |(-1.84,4.02,;-2.24,2.53,;-1.15,1.44,;.38,1.6,;1.15,2.93,;2.69,2.93,;.38,4.27,;1.01,.19,;-.14,-.84,;-1.47,-.07,;-2.8,-.84,;-4.14,-.07,;-5.47,-.84,;-5.47,-2.38,;-4.14,-3.15,;-2.8,-2.38,;-1.47,-3.15,;-.14,-2.38,;-.14,-3.92,;1.2,-3.15,;2.5,-.2,;3.58,.88,;5.07,.49,;5.47,-1,;4.38,-2.09,;2.89,-1.69,;1.81,-2.78,;2.2,-4.27,)|
Structure
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