| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase haspin |
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| Ligand | BDBM350249 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Haspin Kinase Assay |
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| IC50 | 24.2±n/a nM |
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| Citation |  Pastor Fernández, J; Martínez González, S; Blanco-Aparicio, C; Hernández Higueras, AI; Gómez De La Oliva, CA; Rivero Buceta, V; Riesco Fagundo, RC Condensed tricyclic compounds as protein kinase inhibitors US Patent US10208056 Publication Date 2/19/2019 |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase haspin |
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| Name: | Serine/threonine-protein kinase haspin |
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| Synonyms: | GSG2 | Germ cell-specific gene 2 protein | H-haspin | HASPIN | HASP_HUMAN | Haploid germ cell-specific nuclear protein kinase |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88531.28 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1510616 |
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| Residue: | 798 |
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| Sequence: | MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQS
DDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRA
RPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSP
TPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRAS
LRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSC
QERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQ
KLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSEC
SNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLP
TEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISK
ELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLF
IVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKT
SLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFD
IYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRT
MLNFSSATDLLCQHSLFK
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| BDBM350249 |
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| n/a |
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| Name | BDBM350249 |
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| Synonyms: | US10208056, Compound 76 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H16FN3O2 |
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| Mol. Mass. | 301.3155 |
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| SMILES | NC(=O)c1cc2c(-c3ccncc3OC22CCC2)n1CCF |
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| Structure | 
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