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TargetCathepsin D
LigandBDBM16061
Substrate/CompetitorCathepsin D Peptide Substrate
Meas. Tech.Enzyme Inhibition Measurements
Temperature298.15±n/a K
IC50 280±n/a nM
Commentsextracted
Citation Hanessian, SYun, HHou, YYang, GBayrakdarian, MTherrien, EMoitessier, NRoggo, SVeenstra, STintelnot-Blomley, MRondeau, JMOstermeier, CStrauss, ARamage, PPaganetti, PNeumann, UBetschart, C Structure-based design, synthesis, and memapsin 2 (BACE) inhibitory activity of carbocyclic and heterocyclic peptidomimetics. J Med Chem48:5175-90 (2005) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin D
Name:Cathepsin D
Synonyms:CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:Enzyme
Mol. Mass.:44551.72
Organism:Homo sapiens (Human)
Description:Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVP
AVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIH
HKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFG
EATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQ
PGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSL
MVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQ
AGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM16061
Cathepsin D Peptide Substrate
Name:Cathepsin D Peptide Substrate
Synonyms:n/a
Type:Peptide
Mol. Mass.:2375.29
Organism:n/a
Description:Peptide substrates were obtained from Bachem (Bubendorf, Switzerland).
Residue:20
Sequence:
Mca-GKPILFFRLK(DNP)-D-R-NH2