Reaction Details |
| Report a problem with these data |
Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Ligand | BDBM16105 |
---|
Substrate/Competitor | BDBM16100 |
---|
Meas. Tech. | DHODH Inhibition Assay |
---|
pH | 8±n/a |
---|
Temperature | 295.15±n/a K |
---|
Ki | 6000±2000 nM |
---|
Km | 6600±700 nM |
---|
kcat | 15.4±0.2 1/sec |
---|
Comments | Mixed inhibition. |
---|
Citation | Hurt, DE; Sutton, AE; Clardy, J Brequinar derivatives and species-specific drug design for dihydroorotate dehydrogenase. Bioorg Med Chem Lett16:1610-5 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
---|
|
Dihydroorotate dehydrogenase (quinone), mitochondrial |
---|
Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
Type: | Enzyme |
Mol. Mass.: | 42881.33 |
Organism: | Homo sapiens (Human) |
Description: | Q02127 |
Residue: | 395 |
Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
BDBM16105 |
---|
BDBM16100 |
---|
Name | BDBM16105 |
Synonyms: | 3-carbamoyl-5-{3-[4-(trifluoromethyl)phenyl]phenyl}benzoic acid | 5-carbamoyl-4 -(trifluoromethyl)-1,1 :3 ,1 -terphenyl-3-carboxylic acid | AMX10 | Brequinar-derived asymmetric terphenyl compound |
Type | Small organic molecule |
Emp. Form. | C21H14F3NO3 |
Mol. Mass. | 385.336 |
SMILES | NC(=O)c1cc(cc(c1)-c1cccc(c1)-c1ccc(cc1)C(F)(F)F)C(O)=O |
Structure |
|