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TargetUrokinase-type plasminogen activator
LigandBDBM16141
Substrate/CompetitorBDBM14716
Meas. Tech.Determination of Inhibitor Potency and Selectivity
pH8.1±n/a
Temperature310.15±n/a K
Ki 43±n/a nM
Km90000±n/a nM
Citation Fish, PVBarber, CGBrown, DGButt, RCollis, MGDickinson, RPHenry, BTHorne, VAHuggins, JPKing, EO'gara, MMcCleverty, DMcIntosh, FPhillips, CWebster, R Selective Urokinase-Type Plasminogen Activator Inhibitors. 4. 1-(7-Sulfonamidoisoquinolinyl)guanidines. J Med Chem50:2341-51 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Urokinase-type plasminogen activator
Name:Urokinase-type plasminogen activator
Synonyms:PLAU | U-plasminogen activator | UROK_HUMAN | Urokinase | Urokinase-type plasminogen activator (uPA) | Urokinase-type plasminogen activator/surface receptor
Type:Enzyme
Mol. Mass.:48528.62
Organism:Homo sapiens (Human)
Description:P00749
Residue:431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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  Blast E-value cutoff:
BDBM16141
BDBM14716
NameBDBM16141
Synonyms:1-guanidino-7-sulfonamidoisoquinoline 15 | 3-({4-chloro-1-[(diaminomethylidene)amino]isoquinoline-7-}sulfonamido)-2,2-dimethylpropanoic acid
TypeSmall organic molecule
Emp. Form.C15H18ClN5O4S
Mol. Mass.399.853
SMILES[#6]C([#6])([#6]-[#7]S(=O)(=O)c1ccc2c(Cl)cnc(\[#7]=[#6](/[#7])-[#7])c2c1)[#6](-[#8])=O
Structure
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