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TargetBeta-secretase 1 [22-454]
LigandBDBM16288
Substrate/Competitorfluorescent substrate FS-2
Meas. Tech.Enzyme Inhibition Assay
pH4.5±n/a
Temperature295.15±n/a K
Ki 11300±1500 nM
Citation Yang, WLu, WLu, YZhong, MSun, JThomas, AEWilkinson, JMFucini, RVLam, MRandal, MShi, XPJacobs, JWMcDowell, RSGordon, EMBallinger, MD Aminoethylenes: a tetrahedral intermediate isostere yielding potent inhibitors of the aspartyl protease BACE-1. J Med Chem49:839-42 (2006) [PubMed]  Article
More Info.:Get all data from this article,  Inhibition_Run data,   Solution Info,  Assay Method
 
Beta-secretase 1 [22-454]
Name:Beta-secretase 1 [22-454]
Synonyms:ASP2 | Asp 2 | Aspartyl protease 2 | BACE | BACE1 | BACE1_HUMAN | Beta-site APP cleaving enzyme 1 | Beta-site amyloid precursor protein cleaving enzyme 1 | KIAA1149 | Memapsin-2 | Membrane-associated aspartic protease 2 | beta-Secretase (BACE-1)
Type:Enzyme
Mol. Mass.:48079.72
Organism:Homo sapiens (Human)
Description:C-terminally 6XHis-tagged human proBACE-1 (residues 22-454, numbering starting from the N-terminal methionine) was expressed in Hi5 cells using the baculovirus expression vector pFastbac1 (Invitrogen) and purified on Ni-NTA fast flow resin (Qiagen).
Residue:433
Sequence:
TQHGIRLPLRSGLGGAPLGLRLPRETDEEPEEPGRRGSFVEMVDNLRGKSGQGYYVEMTV
GSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGEL
GTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSL
VKQTHVPNLFSLQLCGAGFPLNQSEVLASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYE
VIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDG
FWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCY
KFAISQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTLDME
DCGYNIPQTDEST
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM16288
fluorescent substrate FS-2
Name:fluorescent substrate FS-2
Synonyms:n/a
Type:Peptide
Mol. Mass.:4309.84
Organism:n/a
Description:n/a
Residue:42
Sequence:
MOCAc-Ser-Glu-Val-Asn-Leu-Asp-Ala-Glu-Phe-Lys(DNP)-Arg-Arg-C
OOH