| Reaction Details |
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 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Ligand | BDBM15339 |
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| Substrate/Competitor | BDBM14700 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 303.15±n/a K |
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| IC50 | 367±10 nM |
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| Citation |  Hansen, M; Le Nours, J; Johansson, E; Antal, T; Ullrich, A; Loffler, M; Larsen, S Inhibitor binding in a class 2 dihydroorotate dehydrogenase causes variations in the membrane-associated N-terminal domain. Protein Sci13:1031-42 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Inhibition_Run data, Solution Info, Assay Method |
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| Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
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| Synonyms: | DHOdehase | Dhodh | Dihydroorotate Dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial precursor | Dihydroorotate oxidase | PYRD_RAT |
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| Type: | Enzyme |
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| Mol. Mass.: | 42672.97 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | The enzyme assay was performed with the histidine-tagged enzyme without cleavage of the tag. |
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| Residue: | 395 |
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| Sequence: | MAWRQLRKRALDAVIILGGGGLLFTSYLTATGDDHFYAEYLMPGLQRLLDPESAHRLAVR
VTSLGLLPRATFQDSDMLEVKVLGHKFRNPVGIAAGFDKNGEAVDGLYKLGFGFVEVGSV
TPQPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAQLTADGLPLGIN
LGKNKTSEDAAADYAEGVRTLGPLADYLVVNVSSPNTAGLRSLQGKTELRHLLSKVLQER
DALKGTRKPAVLVKIAPDLTAQDKEDIASVARELGIDGLIVTNTTVSRPVGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRIPIIGVGGVSSGQDALEKIQAGASLVQLYTALIF
LGPPVVVRVKRELEALLKERGFTTVTDAIGADHRR
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| BDBM15339 |
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| BDBM14700 |
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| Name | BDBM15339 |
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| Synonyms: | 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methyl-quinoline-4-carboxylic acid | 6-fluoro-2-[4-(2-fluorophenyl)phenyl]-3-methylquinoline-4-carboxylic acid | Biphenquinate | Brequinar |
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| Type | Small organic molecule |
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| Emp. Form. | C23H15F2NO2 |
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| Mol. Mass. | 375.3675 |
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| SMILES | Cc1c(nc2ccc(F)cc2c1C(O)=O)-c1ccc(cc1)-c1ccccc1F |
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| Structure | 
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