Reaction Details | |||
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Target | Vascular endothelial growth factor receptor 2 | ||
Ligand | BDBM227926 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | KDR (VEGFR-2) Kinase Assay | ||
pH | 7±n/a | ||
IC50 | 0.325±n/a nM | ||
Comments | extracted | ||
Citation | Schall, A; Klar, J; Lobell, M; Schirok, H; Telser, J; Müller, S; Brohm, D; Briem, H; Jörißen, H; Keldenich, J; Böttger, M; Von Degenfeld, G; Schlange, T; Bömer, U; Lindner, N; Eilken, H; Hristodorov, D; Wasnaire, P; Gericke, KM; Bärfacker, L Substituted pyridobenzodiazepinone-derivatives and use thereof US Patent US10047096 Publication Date 8/14/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Vascular endothelial growth factor receptor 2 | |||
Name: | Vascular endothelial growth factor receptor 2 | ||
Synonyms: | CD_antigen=CD309 | FLK1 | Fetal liver kinase 1 (FLK-1) | Flk-1/KDR | KDR | Kinase Insert Domain Receptor | Protein-tyrosine kinase receptor Flk-1 | VEGFR kinase (KDR) | VEGFR-2 | VEGFR-2 (KDR) | VEGFR2 | VGFR2_HUMAN | Vascular Endothelial Growth Factor Receptor Kinase 2 | Vascular endothelial growth factor receptor (VEGFR-2) | Vascular endothelial growth factor receptor 2 (KDR) | Vascular endothelial growth factor receptor 2 (VEGFR-2) | Vascular endothelial growth factor receptor 2 (VEGFR2) | Vascular endothelial growth factor receptor 2 precursor (VEGFR-2) | Vascular endothelial growth factor receptor-2 (VEGFR-2) | ||
Type: | Receptor Tyrosine Kinase | ||
Mol. Mass.: | 151510.97 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P35968 | ||
Residue: | 1356 | ||
Sequence: |
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BDBM227926 | |||
n/a | |||
Name | BDBM227926 | ||
Synonyms: | 4-[(2-Fluoro-5-hydroxy-4-methylphenyl)amino]-8-{[(3-hydroxycyclobutyl)amino]methyl}-6,11-dihydro-5H-pyrido[2,3-b][1,5]benzodiazepin-5-one | US10047096, 187 | ||
Type | Small organic molecule | ||
Emp. Form. | C24H24FN5O3 | ||
Mol. Mass. | 449.4775 | ||
SMILES | Cc1cc(F)c(Nc2ccnc3Nc4ccc(CNC5CC(O)C5)cc4NC(=O)c23)cc1O |(-9.65,3.64,;-8.32,2.87,;-8.32,1.33,;-6.99,.56,;-6.99,-.98,;-5.65,1.33,;-4.32,.56,;-4.32,-.98,;-5.65,-1.75,;-5.65,-3.29,;-4.32,-4.06,;-2.99,-3.29,;-1.78,-4.25,;-.28,-3.91,;.59,-5.18,;2.12,-5.06,;2.79,-3.68,;4.33,-3.68,;5.1,-2.34,;6.43,-1.57,;7.92,-1.97,;8.32,-.48,;9.65,.29,;6.83,-.09,;1.92,-2.41,;.39,-2.52,;-.28,-1.13,;-1.78,-.79,;-2.18,.7,;-2.99,-1.75,;-5.65,2.87,;-6.99,3.64,;-6.99,5.18,)| | ||
Structure |