| Reaction Details |
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 | Report a problem with these data |
| Target | Prothrombin |
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| Ligand | BDBM16307 |
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| Substrate/Competitor | BDBM12679 |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 8.2±n/a |
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| Temperature | 295.15±n/a K |
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| Ki | 10500±n/a nM |
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| Citation |  Katz, BA; Clark, JM; Finer-Moore, JS; Jenkins, TE; Johnson, CR; Ross, MJ; Luong, C; Moore, WR; Stroud, RM Design of potent selective zinc-mediated serine protease inhibitors. Nature391:608-12 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Prothrombin |
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| Name: | Prothrombin |
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| Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
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| Type: | Protein |
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| Mol. Mass.: | 70029.57 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P00734 |
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| Residue: | 622 |
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| Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
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| BDBM16307 |
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| BDBM12679 |
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| Name | BDBM16307 |
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| Synonyms: | 2-(pyridin-2-ylmethyl)-1H-1,3-benzodiazole-6-carboximidamide | 2-(pyridin-2-ylmethyl)-1H-benzimidazole-6-carboximidamide | APD-5 | CHEMBL204126 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H13N5 |
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| Mol. Mass. | 251.2865 |
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| SMILES | NC(=N)c1ccc2nc(Cc3ccccn3)[nH]c2c1 |
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| Structure | 
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