Reaction Details |
| Report a problem with these data |
Target | Aldo-keto reductase family 1 member B1 [W220Y,C299A] |
---|
Ligand | BDBM16425 |
---|
Substrate/Competitor | BDBM16416 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
Ki | 11000±n/a nM |
---|
Citation | Brownlee, JM; Carlson, E; Milne, AC; Pape, E; Harrison, DH Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg Chem34:424-44 (2006) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Aldo-keto reductase family 1 member B1 [W220Y,C299A] |
---|
Name: | Aldo-keto reductase family 1 member B1 [W220Y,C299A] |
Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldose Reductase (ALR2) Mutant (C299A/W220Y) |
Type: | Enzyme |
Mol. Mass.: | 35800.39 |
Organism: | Homo sapiens (Human) |
Description: | P15121[W220Y,C299A] |
Residue: | 316 |
Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPYAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVAA
LLSCTSHKDYPFHEEF
|
|
|
BDBM16425 |
---|
BDBM16416 |
---|
Name | BDBM16425 |
Synonyms: | 2-(2-bromophenyl)acetic acid | 2-Bromophenylacetic acid | EINECS 242-509-2 | o-Bromophenylacetic acid |
Type | Small organic molecule |
Emp. Form. | C8H7BrO2 |
Mol. Mass. | 215.044 |
SMILES | OC(=O)Cc1ccccc1Br |
Structure |
|