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TargetCathepsin B
LigandBDBM16511
Substrate/CompetitorBDBM16498
Meas. Tech.Inhibitory Activity Measurement of Bovine Cathepsin B.
pH6±n/a
Temperature313.15±n/a K
CommentsThe second order rate constant, k2 =1520000 M-1s-1.
Citation Watanabe, DYamamoto, ATomoo, KMatsumoto, KMurata, MKitamura, KIshida, T Quantitative evaluation of each catalytic subsite of cathepsin B for inhibitory activity based on inhibitory activity-binding mode relationship of epoxysuccinyl inhibitors by X-ray crystal structure analyses of complexes. J Mol Biol362:979-93 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Cathepsin B
Name:Cathepsin B
Synonyms:BCSB | CATB_BOVIN | CTSB | Cathepsin B precursor | Cathepsin B1
Type:Enzyme
Mol. Mass.:36657.87
Organism:Bos taurus (bovine)
Description:Bovine spleen CB was purchased from Sigma Co. (USA).
Residue:335
Sequence:
MWRLLATLSCLLVLTSARSSLYFPPLSDELVNFVNKQNTTWKAGHNFYNVDLSYVKKLCG
AILGGPKLPQRDAFAADVVLPESFDAREQWPNCPTIKEIRDQGSCGSCWAFGAVEAISDR
ICIHSNGRVNVEVSAEDMLTCCGGECGDGCNGGFPSGAWNFWTKKGLVSGGLYNSHVGCR
PYSIPPCEHHVNGSRPPCTGEGDTPKCSKTCEPGYSPSYKEDKHFGCSSYSVANNEKEIM
AEIYKNGPVEGAFSVYSDFLLYKSGVYQHVSGEIMGGHAIRILGWGVENGTPYWLVGNSW
NTDWGDNGFFKILRGQDHCGIESEIVAGMPCTHQY
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  Blast E-value cutoff:
BDBM16511
BDBM16498
NameBDBM16511
Synonyms:(2S)-1-[(2S)-2-{[(2S,3S)-3-{[(1S)-1-({[(2-methoxy-2-oxoethyl)carbamoyl]methyl}carbamoyl)-3-methylbutyl]carbamoyl}oxiran-2-yl]formamido}-4-methylpentanoyl]pyrrolidine-2-carboxylic acid | MeO-Gly-Gly-Leu-NH-tES-Leu-Pro-OH | epoxysuccinyl derivative NS134 | methyl N-{[(2S,3S)-3-{[(1S)-1-{[(2S)-2-carboxypyrrolidin-1-yl]carbonyl}-3-methylbutyl]carbamoyl}oxiran-2-yl]carbonyl}-L-leucylglycylglycinate
TypeSmall organic molecule
Emp. Form.C26H41N5O10
Mol. Mass.583.6312
SMILES[H][C@@]1(O[C@]1([H])C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)NCC(=O)OC |r|
Structure
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