| Reaction Details |
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 | Report a problem with these data |
| Target | cAMP-dependent protein kinase catalytic subunit alpha |
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| Ligand | BDBM16586 |
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| Substrate/Competitor | biotinylated kemptide |
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| Meas. Tech. | PKA/PKC Kinase Assay |
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| IC50 | 15±n/a nM |
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| Citation |  Zhu, GD; Gandhi, VB; Gong, J; Thomas, S; Woods, KW; Song, X; Li, T; Diebold, RB; Luo, Y; Liu, X; Guan, R; Klinghofer, V; Johnson, EF; Bouska, J; Olson, A; Marsh, KC; Stoll, VS; Mamo, M; Polakowski, J; Campbell, TJ; Martin, RL; Gintant, GA; Penning, TD; Li, Q; Rosenberg, SH; Giranda, VL Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension. J Med Chem50:2990-3003 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| cAMP-dependent protein kinase catalytic subunit alpha |
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| Name: | cAMP-dependent protein kinase catalytic subunit alpha |
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| Synonyms: | KAPCA_BOVIN | PKA C-alpha | PKC | PRKACA | Protein Kinase C | Protein Kinase C, bovine brain | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent Protein Kinase, bovine heart | cAMP-dependent protein kinase A | cAMP-dependent protein kinase alpha-catalytic subunit | cAMP-dependent protein kinase, alpha-catalytic subunit |
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| Type: | Enzyme Complex |
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| Mol. Mass.: | 40627.77 |
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| Organism: | Bos taurus (bovine) |
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| Description: | The PKA holoenzyme purified from bovine heart, exists as an inactive tetrameric complex, which consists of a regulatory dimer associated with two catalytic subunits. It requires cAMP to activate the enzymatic reaction. |
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| Residue: | 351 |
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| Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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| BDBM16586 |
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| biotinylated kemptide |
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| Name: | biotinylated kemptide |
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| Synonyms: | n/a |
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| Type: | Biotinylated Peptide |
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| Mol. Mass.: | 1353.09 |
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| Organism: | n/a |
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| Description: | n/a |
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| Residue: | 12 |
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| Sequence: | |
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