Reaction Details |
| Report a problem with these data |
Target | Diacylglycerol O-acyltransferase 1 |
---|
Ligand | BDBM351918 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Lipid Extraction (LE) Assay |
---|
IC50 | 0.500±n/a nM |
---|
Citation | Cheung, M; Tangirala, RS Compounds as diacylglycerol acyltransferase inhibitors US Patent US9796729 Publication Date 10/24/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Diacylglycerol O-acyltransferase 1 |
---|
Name: | Diacylglycerol O-acyltransferase 1 |
Synonyms: | ACAT-related gene product 1 | AGRP1 | Acyl coA-diacylglycerol acyl transferase 1 (DGAT1) | DGAT | DGAT1 | DGAT1_HUMAN | Diacylglycerol Acyltransferase (DGAT1) | Diacylglycerol O-acyltransferase 1 | Diacylglycerol O-acyltransferase 1 (DGAT1) | Diglyceride acyltransferase |
Type: | Protein |
Mol. Mass.: | 55297.82 |
Organism: | Homo sapiens (Human) |
Description: | O75907 |
Residue: | 488 |
Sequence: | MGDRGSSRRRRTGSRPSSHGGGGPAAAEEEVRDAAAGPDVGAAGDAPAPAPNKDGDAGVG
SGHWELRCHRLQDSLFSSDSGFSNYRGILNWCVVMLILSNARLFLENLIKYGILVDPIQV
VSLFLKDPYSWPAPCLVIAANVFAVAAFQVEKRLAVGALTEQAGLLLHVANLATILCFPA
AVVLLVESITPVGSLLALMAHTILFLKLFSYRDVNSWCRRARAKAASAGKKASSAAAPHT
VSYPDNLTYRDLYYFLFAPTLCYELNFPRSPRIRKRFLLRRILEMLFFTQLQVGLIQQWM
VPTIQNSMKPFKDMDYSRIIERLLKLAVPNHLIWLIFFYWLFHSCLNAVAELMQFGDREF
YRDWWNSESVTYFWQNWNIPVHKWCIRHFYKPMLRRGSSKWMARTGVFLASAFFHEYLVS
VPLRMFRLWAFTGMMAQIPLAWFVGRFFQGNYGNAAVWLSLIIGQPIAVLMYVHDYYVLN
YEAPAAEA
|
|
|
BDBM351918 |
---|
n/a |
---|
Name | BDBM351918 |
Synonyms: | 4-Amino-6-(1-(3-(trifluoromethoxy)phenyl)-1H-indol-5-yl)-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-5(6H)-one | US9796729, 2 |
Type | Small organic molecule |
Emp. Form. | C22H16F3N5O3 |
Mol. Mass. | 455.3893 |
SMILES | Nc1ncnc2OCCN(c3ccc4n(ccc4c3)-c3cccc(OC(F)(F)F)c3)C(=O)c12 |
Structure |
|