| Reaction Details |
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 | Report a problem with these data |
| Target | Aldo-keto reductase family 1 member B1 |
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| Ligand | BDBM16634 |
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| Substrate/Competitor | BDBM16443 |
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| Meas. Tech. | In Vitro Aldose Reductase Inhibition Assay |
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| IC50 | 5±n/a nM |
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| Citation |  Mylari, BL; Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; O'Gorman, MT; Linhares, MC; Martin, WH; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners. J Med Chem48:6326-39 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Solution Info, Assay Method |
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| Aldo-keto reductase family 1 member B1 |
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| Name: | Aldo-keto reductase family 1 member B1 |
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| Synonyms: | AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR) |
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| Type: | Protein |
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| Mol. Mass.: | 35855.50 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0 |
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| Residue: | 316 |
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| Sequence: | MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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| BDBM16634 |
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| BDBM16443 |
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| Name | BDBM16634 |
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| Synonyms: | 6-{[3-methyl-5-(trifluoromethyl)-1-benzofuran-2-]sulfonyl}-2,3-dihydropyridazin-3-one | Heterocyclic Sulfonylpyridazinone, 19p |
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| Type | Small organic molecule |
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| Emp. Form. | C14H9F3N2O4S |
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| Mol. Mass. | 358.292 |
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| SMILES | Cc1c(oc2ccc(cc12)C(F)(F)F)S(=O)(=O)c1ccc(=O)[nH]n1 |
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| Structure | 
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