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TargetProteinase-activated receptor 4
LigandBDBM176179
Substrate/Competitorn/a
Meas. Tech. PAR4 FLIPR assay
Temperature298.15±n/a K
EC50 0.290±n/a nM
Commentsextracted
Citation Banville, JRemillard, RRuediger, EHDeon, DHGagnon, MDube, LGuy, JPriestley, ESPosy, SLMaxwell, BDWong, PCLawrence, RMMiller, MM Imidazothiadiazole and imidazopyrazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US10047103 Publication Date 8/14/2018
More Info.:Get all data from this article,  Assay Method
 
Proteinase-activated receptor 4
Name:Proteinase-activated receptor 4
Synonyms:Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3
Type:Protein
Mol. Mass.:41145.16
Organism:Homo sapiens (Human)
Description:Q96RI0
Residue:385
Sequence:
MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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  Blast E-value cutoff:
BDBM176179
n/a
NameBDBM176179
Synonyms:US10047103, 212 | US9688695, 212
TypeSmall organic molecule
Emp. Form.C25H23FN4O4S
Mol. Mass.494.538
SMILESCOc1cc(OCc2csc(n2)C2(F)CCOCC2)c2cc(oc2c1)-c1cn2nc(C)ccc2n1
Structure
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