| Reaction Details |
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 | Report a problem with these data |
| Target | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 |
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| Ligand | BDBM351932 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 480±n/a nM |
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| Citation |  Maloney, DJ; Rosenthal, AS; Jadhav, A; Dexheimer, TS; Simeonov, A; Zhuang, Z; Liang, Q; Luci, DK Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof US Patent US9802904 Publication Date 10/31/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 |
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| Name: | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 |
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| Synonyms: | USP1/UAF1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | n/a |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | WD repeat-containing protein 48 |
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| Synonyms: | KIAA1449 | UAF1 | USP1-associated factor 1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 | WD repeat endosomal protein | WD repeat-containing protein 48 | WDR48 | WDR48_HUMAN | p80 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 76215.66 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_109642 |
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| Residue: | 677 |
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| Sequence: | MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVN
QHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYV
KALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLG
TIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLG
QQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKM
ELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGG
ASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWF
SVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVN
PMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESM
LLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHV
YEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHF
IWKSGGDLTLHYRQKST
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| Component 2 |
| Name: | Ubiquitin carboxyl-terminal hydrolase 1 |
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| Synonyms: | Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48Â | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP |
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| Type: | PROTEIN |
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| Mol. Mass.: | 88191.62 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_104169 |
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| Residue: | 785 |
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| Sequence: | MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQV
VPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKK
EALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRR
LLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPK
EEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQT
RSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGK
ITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQ
IGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKT
EMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGL
EFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKV
TDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNK
KNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSD
QTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLL
FYKKL
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| BDBM351932 |
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| n/a |
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| Name | BDBM351932 |
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| Synonyms: | US9802904, 65 |
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| Type | Small organic molecule |
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| Emp. Form. | C27H27N3 |
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| Mol. Mass. | 393.5234 |
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| SMILES | CC(C)c1ccccc1-c1nc(C)cc(NCc2ccc(cc2)-c2ccccc2)n1 |
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| Structure | 
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