Reaction Details |
| Report a problem with these data |
Target | Beta-secretase 2 |
---|
Ligand | BDBM352252 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | HTRF Assay |
---|
Ki | 8.00±n/a nM |
---|
Citation | Scott, JD; Cumming, JN; Blizzard, T; Ellis, M C-6 spirocarbocyclic iminothiadiazine dioxides as BACE inhibitors, compositions, and their use US Patent US9802928 Publication Date 10/31/2017 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Beta-secretase 2 |
---|
Name: | Beta-secretase 2 |
Synonyms: | AEPLC | ALP56 | ASP1 | ASP21 | Asp 1 | Aspartic-like protease 56 kDa | Aspartyl protease 1 | BACE2 | BACE2_HUMAN | Beta secretase 2 | Beta-secretase (BACE) | Beta-secretase 2 | Beta-secretase 2 (BACE-2) | Beta-secretase 2 precursor | Beta-site APP-cleaving enzyme 2 | Down region aspartic protease | Memapsin-1 | Membrane-associated aspartic protease 1 | beta-Secretase (BACE-2) |
Type: | Protein |
Mol. Mass.: | 56171.20 |
Organism: | Homo sapiens (Human) |
Description: | Q9Y5Z0 |
Residue: | 518 |
Sequence: | MGALARALLLPLLAQWLLRAAPELAPAPFTLPLRVAAATNRVVAPTPGPGTPAERHADGL
ALALEPALASPAGAANFLAMVDNLQGDSGRGYYLEMLIGTPPQKLQILVDTGSSNFAVAG
TPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATI
FESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVA
GSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKA
IVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISI
YLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFD
RAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCG
AILLVLIVLLLLPFRCQRRPRDPEVVNDESSLVRHRWK
|
|
|
BDBM352252 |
---|
n/a |
---|
Name | BDBM352252 |
Synonyms: | US9802928, 1h |
Type | Small organic molecule |
Emp. Form. | C17H19FN6O4S |
Mol. Mass. | 422.434 |
SMILES | CN1C(=N)N[C@](C)(c2cc(NC(=O)c3noc(C)n3)ccc2F)C2(CC2)S1(=O)=O |r| |
Structure |
|