Reaction Details |
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Target | cAMP-dependent protein kinase catalytic subunit alpha |
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Ligand | BDBM16978 |
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Substrate/Competitor | biotinylated kemptide |
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Meas. Tech. | PKA/PKC Kinase Assay |
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IC50 | 8±n/a nM |
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Citation | Zhu, GD; Gong, J; Claiborne, A; Woods, KW; Gandhi, VB; Thomas, S; Luo, Y; Liu, X; Shi, Y; Guan, R; Magnone, SR; Klinghofer, V; Johnson, EF; Bouska, J; Shoemaker, A; Oleksijew, A; Stoll, VS; De Jong, R; Oltersdorf, T; Li, Q; Rosenberg, SH; Giranda, VL Isoquinoline-pyridine-based protein kinase B/Akt antagonists: SAR and in vivo antitumor activity. Bioorg Med Chem Lett16:3150-5 (2006) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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cAMP-dependent protein kinase catalytic subunit alpha |
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Name: | cAMP-dependent protein kinase catalytic subunit alpha |
Synonyms: | KAPCA_BOVIN | PKA C-alpha | PKC | PRKACA | Protein Kinase C | Protein Kinase C, bovine brain | cAMP-Dependent Protein Kinase (PKA) | cAMP-dependent Protein Kinase, bovine heart | cAMP-dependent protein kinase A | cAMP-dependent protein kinase alpha-catalytic subunit | cAMP-dependent protein kinase, alpha-catalytic subunit |
Type: | Enzyme Complex |
Mol. Mass.: | 40627.77 |
Organism: | Bos taurus (bovine) |
Description: | The PKA holoenzyme purified from bovine heart, exists as an inactive tetrameric complex, which consists of a regulatory dimer associated with two catalytic subunits. It requires cAMP to activate the enzymatic reaction. |
Residue: | 351 |
Sequence: | MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
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BDBM16978 |
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biotinylated kemptide |
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Name: | biotinylated kemptide |
Synonyms: | n/a |
Type: | Biotinylated Peptide |
Mol. Mass.: | 1353.09 |
Organism: | n/a |
Description: | n/a |
Residue: | 12 |
Sequence: | |