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Target3-phosphoinositide-dependent protein kinase 1 [51-359,V143T]
LigandBDBM17055
Substrate/CompetitorPDKtide
Meas. Tech.PDK1 Kinase Activity Assay
pH7.5±n/a
Temperature303.15±n/a K
IC50 500±n/a nM
Citation Komander, DKular, GSSchüttelkopf, AWDeak, MPrakash, KRBain, JElliott, MGarrido-Franco, MKozikowski, APAlessi, DRvan Aalten, DM Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1. Structure12:215-26 (2004) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
3-phosphoinositide-dependent protein kinase 1 [51-359,V143T]
Name:3-phosphoinositide-dependent protein kinase 1 [51-359,V143T]
Synonyms:3-Phosphoinositide-Dependent Protein Kinase 1 (PDK1) Mutant (V143T) | 3-phosphoinositide-dependent protein kinase 1 | PDK1 | PDPK1 | PDPK1_HUMAN | hPDK1
Type:Kinase domain
Mol. Mass.:35304.23
Organism:Homo sapiens (Human)
Description:The mutant enzyme was generated using site-directed mutagenesis and expressed as glutathione-S-transferase (GST) fusion proteins in insect cells.
Residue:309
Sequence:
MDGTAAEPRPGAGSLQHAQPPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAI
KILEKRHIIKENKVPYVTRERDVMSRLDHPFFTKLYFTFQDDEKLYFGLSYAKNGELLKY
IRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVL
SPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLI
FQKIIKLEYDFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFESVTWENL
HQQTPPKLT
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM17055
PDKtide
Name:PDKtide
Synonyms:Synthetic PDK substrate peptide
Type:Peptide
Mol. Mass.:4766.24
Organism:n/a
Description:n/a
Residue:39
Sequence:
KTFCGTPEYLAPEVRREPRILSEEEQEMFRDFDYIADWC