Reaction Details |
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Target | Serine protease 1 |
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Ligand | BDBM17111 |
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Substrate/Competitor | BDBM17139 |
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Meas. Tech. | Enzyme Inhibition Assay |
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Ki | >10000±n/a nM |
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Citation | Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors J Med Chem50:2967-80 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Solution Info, Assay Method |
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Serine protease 1 |
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Name: | Serine protease 1 |
Synonyms: | Beta-Trypsin | Cationic trypsin | PRSS1 | TRP1 | TRY1 | TRY1_BOVIN | TRYP1 | Trypsin | Trypsin I |
Type: | Enzyme |
Mol. Mass.: | 25790.52 |
Organism: | Bos taurus (bovine) |
Description: | P00760 |
Residue: | 246 |
Sequence: | MKTFIFLALLGAAVAFPVDDDDKIVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVS
AAHCYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNTLNNDIMLIKLKSAASLN
SRVASISLPTSCASAGTQCLISGWGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQIT
SNMFCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQKNKPGVYTKVCNYVSWIK
QTIASN
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BDBM17111 |
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BDBM17139 |
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Name | BDBM17111 |
Synonyms: | 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[4,5-dihydro-1,3-oxazol-2-yl(methyl)amino]methyl}thiophene-2-carboxamide | Thiophene-Anthranilamide, 13a | ZK 810388 | ZK810388 |
Type | Small organic molecule |
Emp. Form. | C23H20Cl3N5O4S |
Mol. Mass. | 568.86 |
SMILES | COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)C2=NCCO2)c1Cl |t:31| |
Structure |
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