Reaction Details |
| Report a problem with these data |
Target | Prothrombin |
---|
Ligand | BDBM17104 |
---|
Substrate/Competitor | BDBM12680 |
---|
Meas. Tech. | Enzyme Inhibition Assay |
---|
Ki | 190±n/a nM |
---|
Citation | Ye, B; Arnaiz, DO; Chou, YL; Griedel, BD; Karanjawala, R; Lee, W; Morrissey, MM; Sacchi, KL; Sakata, ST; Shaw, KJ; Wu, SC; Zhao, Z; Adler, M; Cheeseman, S; Dole, WP; Ewing, J; Fitch, R; Lentz, D; Liang, A; Light, D; Morser, J; Post, J; Rumennik, G; Subramanyam, B; Sullivan, ME; Vergona, R; Walters, J; Wang, YX; White, KA; Whitlow, M; Kochanny, MJ Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors J Med Chem50:2967-80 (2007) [PubMed] Article |
---|
More Info.: | Get all data from this article, Solution Info, Assay Method |
---|
|
Prothrombin |
---|
Name: | Prothrombin |
Synonyms: | Activation peptide fragment 1 | Activation peptide fragment 2 | Coagulation factor II | F2 | Prothrombin precursor | THRB_HUMAN | Thrombin heavy chain | Thrombin light chain |
Type: | Protein |
Mol. Mass.: | 70029.57 |
Organism: | Homo sapiens (Human) |
Description: | P00734 |
Residue: | 622 |
Sequence: | MAHVRGLQLPGCLALAALCSLVHSQHVFLAPQQARSLLQRVRRANTFLEEVRKGNLEREC
VEETCSYEEAFEALESSTATDVFWAKYTACETARTPRDKLAACLEGNCAEGLGTNYRGHV
NITRSGIECQLWRSRYPHKPEINSTTHPGADLQENFCRNPDSSTTGPWCYTTDPTVRRQE
CSIPVCGQDQVTVAMTPRSEGSSVNLSPPLEQCVPDRGQQYQGRLAVTTHGLPCLAWASA
QAKALSKHQDFNSAVQLVENFCRNPDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETG
DGLDEDSDRAIEGRTATSEYQTFFNPRTFGSGEADCGLRPLFEKKSLEDKTERELLESYI
DGRIVEGSDAEIGMSPWQVMLFRKSPQELLCGASLISDRWVLTAAHCLLYPPWDKNFTEN
DLLVRIGKHSRTRYERNIEKISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHP
VCLPDRETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCKDST
RIRITDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNRWYQMGIVSWGEGCDRDGKY
GFYTHVFRLKKWIQKVIDQFGE
|
|
|
BDBM17104 |
---|
BDBM12680 |
---|
Name | BDBM17104 |
Synonyms: | 3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-({methyl[2-(pyrrolidin-1-yl)ethyl]amino}methyl)thiophene-2-carboxamide | Thiophene-Anthranilamide, 10p |
Type | Small organic molecule |
Emp. Form. | C26H28Cl3N5O3S |
Mol. Mass. | 596.956 |
SMILES | COc1cc(Cl)cc(C(=O)Nc2ccc(Cl)cn2)c1NC(=O)c1scc(CN(C)CCN2CCCC2)c1Cl |
Structure |
|