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TargetFactor Xa (fXa)
LigandBDBM17135
Substrate/CompetitorBDBM12658
Meas. Tech.Enzyme Inhibition Assay
Ki 0.31±n/a nM
Citation Ye BArnaiz DOChou YLGriedel BDKaranjawala RLee WMorrissey MMSacchi KLSakata STShaw KJWu SCZhao ZAdler MCheeseman SDole WPEwing JFitch RLentz DLiang ALight DMorser JPost JRumennik GSubramanyam BSullivan MEVergona RWalters JWang YXWhite KAWhitlow MKochanny MJ Thiophene-anthranilamides as highly potent and orally available factor xa inhibitors J Med Chem 50:2967-80 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Factor Xa (fXa)
Name:Factor Xa (fXa)
Synonyms:Coagulation factor X precursor | Stuart factor | Stuart-Prower factor
Type:Enzyme
Mol. Mass.:17844.67
Organism:Canis lupus familiaris (Dog)
Description:n/a
Residue:159
Sequence:
ILSEYYILTAAHCLQQAKKFTVRVGERDTDKEEGNEVAHEVEMIIKHNKFVRETYDFDIA
VIKLKTPITFRMNVAPACLPQKDWAESTLMTQKTGIVSGFGKTHEKGRPSTTLKMMEVPY
VDRNTCKLSSSFSITQNMFCAGYDSKPEDGCQGDSGGPH
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  Blast E-value cutoff:
BDBM17135
BDBM12658
NameBDBM17135
Synonyms:3-chloro-N-{4-chloro-2-[(5-chloropyridin-2-yl)carbamoyl]-6-methoxyphenyl}-4-{[2-(methylamino)-1H-imidazol-1-yl]methyl}thiophene-2-carboxamide | Thiophene-Anthranilamide, 17m | ZK 813039 | ZK813039
TypeSmall organic molecule
Emp. Form.C23H19Cl3N6O3S
Mol. Mass.565.859
SMILESCNc1nccn1Cc1csc(C(=O)Nc2c(OC)cc(Cl)cc2C(=O)Nc2ccc(Cl)cn2)c1Cl
Structure
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