| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Mitogen-activated protein kinase kinase kinase 11 |
|---|
| Ligand | BDBM354780 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Radiometric Filter Plate Assay |
|---|
| IC50 | <100±n/a nM |
|---|
| Citation |  Gelbard, HA; Dewhurst, S; Goodfellow, VS; Loweth, CJ; Wiemann, T Substituted pyrrolo[2,3-b]pyridines as MLK inhibitors US Patent US9814704 Publication Date 11/14/2017 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Mitogen-activated protein kinase kinase kinase 11 |
|---|
| Name: | Mitogen-activated protein kinase kinase kinase 11 |
|---|
| Synonyms: | M3K11_HUMAN | MAP3K11 | MLK3 | Mitogen-activated protein kinase kinase kinase 11 | Mixed Lineage Kinase 3 (MLK3) | PTK1 | SPRK |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 92696.93 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1460565 |
|---|
| Residue: | 847 |
|---|
| Sequence: | MEPLKSLFLKSPLGSWNGSGSGGGGGGGGGRPEGSPKAAGYANPVWTALFDYEPSGQDEL
ALRKGDRVEVLSRDAAISGDEGWWAGQVGGQVGIFPSNYVSRGGGPPPCEVASFQELRLE
EVIGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRQEARLFAMLAHPNIIALK
AVCLEEPNLCLVMEYAAGGPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCEALVPVIHR
DLKSNNILLLQPIESDDMEHKTLKITDFGLAREWHKTTQMSAAGTYAWMAPEVIKASTFS
KGSDVWSFGVLLWELLTGEVPYRGIDCLAVAYGVAVNKLTLPIPSTCPEPFAQLMADCWA
QDPHRRPDFASILQQLEALEAQVLREMPRDSFHSMQEGWKREIQGLFDELRAKEKELLSR
EEELTRAAREQRSQAEQLRRREHLLAQWELEVFERELTLLLQQVDRERPHVRRRRGTFKR
SKLRARDGGERISMPLDFKHRITVQASPGLDRRRNVFEVGPGDSPTFPRFRAIQLEPAEP
GQAWGRQSPRRLEDSSNGERRACWAWGPSSPKPGEAQNGRRRSRMDEATWYLDSDDSSPL
GSPSTPPALNGNPPRPSLEPEEPKRPVPAERGSSSGTPKLIQRALLRGTALLASLGLGRD
LQPPGGPGRERGESPTTPPTPTPAPCPTEPPPSPLICFSLKTPDSPPTPAPLLLDLGIPV
GQRSAKSPRREEEPRGGTVSPPPGTSRSAPGTPGTPRSPPLGLISRPRPSPLRSRIDPWS
FVSAGPRPSPLPSPQPAPRRAPWTLFPDSDPFWDSPPANPFQGGPQDCRAQTKDMGAQAP
WVPEAGP
|
|
|
|---|
| BDBM354780 |
|---|
| n/a |
|---|
| Name | BDBM354780 |
|---|
| Synonyms: | 1-(1H-indol-5-yl)-6-(3- methoxy-4-(2- morpholinoethoxy)phenyl)- 1H-imidazo[4,5-b]pyrazin- 2(3H)-one | US10485800, Example 57 | US9814704, Example 57 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H26N6O4 |
|---|
| Mol. Mass. | 486.5224 |
|---|
| SMILES | COc1cc(ccc1OCCN1CCOCC1)-c1cnc2[nH]c(=O)n(-c3ccc4[nH]ccc4c3)c2n1 |
|---|
| Structure | 
|
|---|
Search and Browse
