| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Integrin alpha-4/beta-1 [T112H] |
|---|
| Ligand | BDBM17189 |
|---|
| Substrate/Competitor | BDBM17155 |
|---|
| Meas. Tech. | Jurkat J6 Scintillation Proximity Assay |
|---|
| pH | 7.5±n/a |
|---|
| Temperature | 295.15±n/a K |
|---|
| Ki | >1000±n/a nM |
|---|
| Citation |  Witherington, J; Bordas, V; Gaiba, A; Green, PM; Naylor, A; Parr, N; Smith, DG; Takle, AK; Ward, RW Pyridone derivatives as potent and selective VLA-4 integrin antagonists. Bioorg Med Chem Lett16:2256-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Solution Info, Assay Method |
|---|
| |
| Integrin alpha-4/beta-1 [T112H] |
|---|
| Name: | Integrin alpha-4/beta-1 [T112H] |
|---|
| Synonyms: | CD49d/CD29 | Integrin alpha4beta1 (VLA-4) | Very Late Antigen-4 |
|---|
| Type: | Protein Complex |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | The assay uses transfected Ramos cells expressing alpha4beta1 integrin. |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | Integrin alpha-4 |
|---|
| Synonyms: | CD49 antigen-like family member D | CD49D | CD49d antigen | CD_antigen=CD49d | ITA4_HUMAN | ITGA4 | Integrin alpha-4 | Integrin alpha-4/beta-7 | Integrin alpha-IV | Integrin alpha4 | VLA-4 | VLA-4 subunit alpha | integrin alpha 4 precursor | integrin alpha-4 precursor |
|---|
| Type: | Membrane Protein |
|---|
| Mol. Mass.: | 114897.35 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P13612 |
|---|
| Residue: | 1032 |
|---|
| Sequence: | MAWEARREPGPRRAAVRETVMLLLCLGVPTGRPYNVDTESALLYQGPHNTLFGYSVVLHS
HGANRWLLVGAPTANWLANASVINPGAIYRCRIGKNPGQTCEQLQLGSPNGEPCGKTCLE
ERDNQWLGVTLSRQPGENGSIVTCGHRWKNIFYIKNENKLPTGGCYGVPPDLRTELSKRI
APCYQDYVKKFGENFASCQAGISSFYTKDLIVMGAPGSSYWTGSLFVYNITTNKYKAFLD
KQNQVKFGSYLGYSVGAGHFRSQHTTEVVGGAPQHEQIGKAYIFSIDEKELNILHEMKGK
KLGSYFGASVCAVDLNADGFSDLLVGAPMQSTIREEGRVFVYINSGSGAVMNAMETNLVG
SDKYAARFGESIVNLGDIDNDGFEDVAIGAPQEDDLQGAIYIYNGRADGISSTFSQRIEG
LQISKSLSMFGQSISGQIDADNNGYVDVAVGAFRSDSAVLLRTRPVVIVDASLSHPESVN
RTKFDCVENGWPSVCIDLTLCFSYKGKEVPGYIVLFYNMSLDVNRKAESPPRFYFSSNGT
SDVITGSIQVSSREANCRTHQAFMRKDVRDILTPIQIEAAYHLGPHVISKRSTEEFPPLQ
PILQQKKEKDIMKKTINFARFCAHENCSADLQVSAKIGFLKPHENKTYLAVGSMKTLMLN
VSLFNAGDDAYETTLHVKLPVGLYFIKILELEEKQINCEVTDNSGVVQLDCSIGYIYVDH
LSRIDISFLLDVSSLSRAEEDLSITVHATCENEEEMDNLKHSRVTVAIPLKYEVKLTVHG
FVNPTSFVYGSNDENEPETCMVEKMNLTFHVINTGNSMAPNVSVEIMVPNSFSPQTDKLF
NILDVQTTTGECHFENYQRVCALEQQKSAMQTLKGIVRFLSKTDKRLLYCIKADPHCLNF
LCNFGKMESGKEASVHIQLEGRPSILEMDETSALKFEIRATGFPEPNPRVIELNKDENVA
HVLLEGLHHQRPKRYFTIVIISSSLLLGLIVLLLISYVMWKAGFFKRQYKSILQEENRRD
SWSYINSKSNDD
|
|
|
|---|
| Component 2 |
| Name: | Integrin beta-1 [T112H] |
|---|
| Synonyms: | CD29 antigen | FNRB | Fibronectin receptor subunit beta | ITB1_HUMAN | ITGB1 | Integrin VLA-4 subunit beta | Integrin beta1 | MDF2 | MSK12 |
|---|
| Type: | Membrane Protein |
|---|
| Mol. Mass.: | 88450.95 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P05556[T112H] |
|---|
| Residue: | 798 |
|---|
| Sequence: | MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPT
SARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDIHQIQPQQLV
LRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDF
RIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTTPFSYKNVLSLTNKGEVFNELVGKQR
ISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQ
CHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTL
SANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISI
GDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEG
NGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRK
RDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE
ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDT
CTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVEN
PECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGEN
PIYKSAVTTVVNPKYEGK
|
|
|
|---|
| BDBM17189 |
|---|
| BDBM17155 |
|---|
| Name | BDBM17189 |
|---|
| Synonyms: | 3-(4-{[5-(3-methoxy-4-{[(2-methylphenyl)carbamoyl]amino}phenyl)-1,3,4-oxadiazol-2-yl]methyl}phenyl)propanoic acid | C-ring heterocyclic urea, 6 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C27H26N4O5 |
|---|
| Mol. Mass. | 486.5191 |
|---|
| SMILES | COc1cc(ccc1NC(=O)Nc1ccccc1C)-c1nnc(Cc2ccc(CCC(O)=O)cc2)o1 |
|---|
| Structure | 
|
|---|
Search and Browse
