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TargetPhosphodiesterase
LigandBDBM355171
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization (FP) Assay
Ki 0.650±n/a nM
Citation Shen, DMEgbertson, MBerger, RQian, XQian, YHarper, BYang, MGuo, ZZRada, VLWang, DCernak, TASinz, CWang, MWilson, JEXu, S Pyrimidone carboxamide compounds as PDE2 inhibitors US Patent US9815796 Publication Date 11/14/2017
More Info.:Get all data from this article,  Assay Method
 
Phosphodiesterase
Name:Phosphodiesterase
Synonyms:PDE2A3 | Phosphodiesterase A3 (PDE2A3)
Type:Enzyme Catalytic Domain
Mol. Mass.:105547.91
Organism:Macaca mulatta (Rhesus macaque)
Description:n/a
Residue:941
Sequence:
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCN
GLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
QDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM355171
n/a
NameBDBM355171
Synonyms:2-cyclopropyl-N-{(1R)-2,2-dimethyl- 1-[4-(trifluoromethyl)phenyl]propyl}- 6-oxo-1,6-dihydropyrimidine-4- carboxamide | US9815796, Example 262
TypeSmall organic molecule
Emp. Form.C20H22F3N3O2
Mol. Mass.393.4028
SMILESCC(C)(C)[C@@H](NC(=O)c1cc(=O)[nH]c(n1)C1CC1)c1ccc(cc1)C(F)(F)F |r|
Structure
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