| Reaction Details |
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 | Report a problem with these data |
| Target | Phosphodiesterase |
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| Ligand | BDBM355366 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarization (FP) Assay |
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| Ki | 0.680±n/a nM |
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| Citation |  Shen, DM; Egbertson, M; Berger, R; Qian, X; Qian, Y; Harper, B; Yang, M; Guo, ZZ; Rada, VL; Wang, D; Cernak, TA; Sinz, C; Wang, M; Wilson, JE; Xu, S Pyrimidone carboxamide compounds as PDE2 inhibitors US Patent US9815796 Publication Date 11/14/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Phosphodiesterase |
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| Name: | Phosphodiesterase |
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| Synonyms: | PDE2A3 | Phosphodiesterase A3 (PDE2A3) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 105547.91 |
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| Organism: | Macaca mulatta (Rhesus macaque) |
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| Description: | n/a |
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| Residue: | 941 |
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| Sequence: | MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESRLVCEDPPHELPQEGKVWEAIISQKRLGCN
GLGLSDLPGKPLARLVAPLAPHTQVLVIPLVDKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQALQQRRPSEAPQAVQNPPEGAVEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDSLQLSCKVMGDKVLGEEISFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
QDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDESTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPEAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTGAPINGCCSLDAE
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| BDBM355366 |
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| n/a |
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| Name | BDBM355366 |
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| Synonyms: | N-{(1R)-2,2-dimethyl-1-[4- (trifluoromethyl)phenyl]propyl}-2- (3-fluoro-4-methoxybenzyl)-6-oxo- 1,6-dihydropyrimidine-4- carboxamide | US9815796, Example 457 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H25F4N3O3 |
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| Mol. Mass. | 491.4779 |
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| SMILES | COc1ccc(Cc2nc(cc(=O)[nH]2)C(=O)N[C@@H](c2ccc(cc2)C(F)(F)F)C(C)(C)C)cc1F |r| |
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| Structure | 
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