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TargetcGMP-dependent 3',5'-cyclic phosphodiesterase
LigandBDBM355437
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarization (FP) Assay
Ki 1.10±n/a nM
Citation Shen, DMEgbertson, MBerger, RQian, XQian, YHarper, BYang, MGuo, ZZRada, VLWang, DCernak, TASinz, CWang, MWilson, JEXu, S Pyrimidone carboxamide compounds as PDE2 inhibitors US Patent US9815796 Publication Date 11/14/2017
More Info.:Get all data from this article,  Assay Method
 
cGMP-dependent 3',5'-cyclic phosphodiesterase
Name:cGMP-dependent 3',5'-cyclic phosphodiesterase
Synonyms:CGS-PDE | Cyclic GMP-stimulated phosphodiesterase | Homo sapiens phosphodiesterase 2A (PDE2A) | NM_002599 | PDE2A | PDE2A_HUMAN | cGSPDE
Type:Enzyme Catalytic Domain
Mol. Mass.:105691.58
Organism:Homo sapiens (Human)
Description:O00408
Residue:941
Sequence:
MGQACGHSILCRSQQYPAARPAEPRGQQVFLKPDEPPPPPQPCADSLQDALLSLGSVIDI
SGLQRAVKEALSAVLPRVETVYTYLLDGESQLVCEDPPHELPQEGKVREAIISQKRLGCN
GLGFSDLPGKPLARLVAPLAPDTQVLVMPLADKEAGAVAAVILVHCGQLSDNEEWSLQAV
EKHTLVALRRVQVLQQRGPREAPRAVQNPPEGTAEDQKGGAAYTDRDRKILQLCGELYDL
DASSLQLKVLQYLQQETRASRCCLLLVSEDNLQLSCKVIGDKVLGEEVSFPLTGCLGQVV
EDKKSIQLKDLTSEDVQQLQSMLGCELQAMLCVPVISRATDQVVALACAFNKLEGDLFTD
EDEHVIQHCFHYTSTVLTSTLAFQKEQKLKCECQALLQVAKNLFTHLDDVSVLLQEIITE
ARNLSNAEICSVFLLDQNELVAKVFDGGVVDDESYEIRIPADQGIAGHVATTGQILNIPD
AYAHPLFYRGVDDSTGFRTRNILCFPIKNENQEVIGVAELVNKINGPWFSKFDEDLATAF
SIYCGISIAHSLLYKKVNEAQYRSHLANEMMMYHMKVSDDEYTKLLHDGIQPVAAIDSNF
ASFTYTPRSLPEDDTSMAILSMLQDMNFINNYKIDCPTLARFCLMVKKGYRDPPYHNWMH
AFSVSHFCYLLYKNLELTNYLEDIEIFALFISCMCHDLDHRGTNNSFQVASKSVLAALYS
SEGSVMERHHFAQAIAILNTHGCNIFDHFSRKDYQRMLDLMRDIILATDLAHHLRIFKDL
QKMAEVGYDRNNKQHHRLLLCLLMTSCDLSDQTKGWKTTRKIAELIYKEFFSQGDLEKAM
GNRPMEMMDREKAYIPELQISFMEHIAMPIYKLLQDLFPKAAELYERVASNREHWTKVSH
KFTIRGLPSNNSLDFLDEEYEVPDLDGTRAPINGCCSLDAE
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  Blast E-value cutoff:
BDBM355437
n/a
NameBDBM355437
Synonyms:2-(3-fluoro-4-methoxybenzyl)-N- {(1R)-1-[3-fluoro-4- (trifluoromethoxy)phenyl]propyl}- 6-oxo-1,6-dihydropyrimidine-4- carboxamide | US9815796, Example 528
TypeSmall organic molecule
Emp. Form.C23H20F5N3O4
Mol. Mass.497.4146
SMILESCC[C@@H](NC(=O)c1cc(=O)[nH]c(Cc2ccc(OC)c(F)c2)n1)c1ccc(OC(F)(F)F)c(F)c1 |r|
Structure
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