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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Rho-associated protein kinase 1 | ||
| Ligand | BDBM355727 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Inhibition Assay | ||
| Ki | 40.0±n/a nM | ||
| Citation |  Poyurovsky, M; Kim, J; Liu, K; Zanin-Zhorov, A Rho kinase inhibitors US Patent US9815820 Publication Date 11/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Rho-associated protein kinase 1 | |||
| Name: | Rho-associated protein kinase 1 | ||
| Synonyms: | ROCK-I | ROCK1 | ROCK1_HUMAN | Renal carcinoma antigen NY-REN-35 | Rho-associated protein kinase | Rho-associated protein kinase 1 (ROCK1) | Rho-associated, coiled-coil-containing protein kinase 1 | Rho-associated, coiled-coil-containing protein kinase I | Rho-kinase (ROCK I) | Serine/threonine-protein kinase RIO1 | p160 ROCK-1 | p160ROCK | ||
| Type: | Serine/threonine-protein kinase | ||
| Mol. Mass.: | 158156.77 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q13464 | ||
| Residue: | 1354 | ||
| Sequence: |
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| BDBM355727 | |||
| n/a | |||
| Name | BDBM355727 | ||
| Synonyms: | US9815820, Y-27263 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C15H22N2O | ||
| Mol. Mass. | 246.348 | ||
| SMILES | CC(C)[C@H]1CC[C@@H](CC1)C(=O)Nc1ccncc1 |r,wU:6.9,wD:3.2,(-5.43,-.71,;-4.66,.62,;-5.43,1.96,;-3.12,.62,;-2.35,-.71,;-.81,-.71,;-.04,.62,;-.81,1.96,;-2.35,1.96,;1.5,.62,;2.27,-.71,;2.27,1.96,;3.81,1.96,;4.58,.62,;6.12,.62,;6.89,1.96,;6.12,3.29,;4.58,3.29,)| | ||
| Structure | 
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