| Reaction Details |
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 | Report a problem with these data |
| Target | Interleukin-1 receptor-associated kinase 1 [194-712] |
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| Ligand | BDBM355852 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Assay |
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| IC50 | <100±n/a nM |
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| Citation |  Chen, X; Yu, H; Lan, R; Jorand-Lebrun, C; Johnson, TL; Goutopoulos, A Macrocyclic compounds as IRAK1/4 inhibitors and uses thereof US Patent US9815836 Publication Date 11/14/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Interleukin-1 receptor-associated kinase 1 [194-712] |
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| Name: | Interleukin-1 receptor-associated kinase 1 [194-712] |
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| Synonyms: | IRAK | IRAK1 | IRAK1_HUMAN | Interleukin-1 receptor-associated kinase 1 (IRAK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 55943.99 |
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| Organism: | Homo sapiens (Human) |
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| Description: | aa 194-712 |
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| Residue: | 519 |
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| Sequence: | RPFPFCWPLCEISRGTHNFSEELKIGEGGFGCVYRAVMRNTVYAVKRLKENADLEWTAVK
QSFLTEVEQLSRFRHPNIVDFAGYCAQNGFYCLVYGFLPNGSLEDRLHCQTQACPPLSWP
QRLDILLGTARAIQFLHQDSPSLIHGDIKSSNVLLDERLTPKLGDFGLARFSRFAGSSPS
QSSMVARTQTVRGTLAYLPEEYIKTGRLAVDTDTFSFGVVVLETLAGQRAVKTHGARTKY
LKDLVEEEAEEAGVALRSTQSTLQAGLAADAWAAPIAMQIYKKHLDPRPGPCPPELGLGL
GQLACCCLHRRAKRRPPMTQVYERLEKLQAVVAGVPGHSEAASCIPPSPQENSYVSSTGR
AHSGAAPWQPLAAPSGASAQAAEQLQRGPNQPVESDESLGGLSAALRSWHLTPSCPLDPA
PLREAGCPQGDTAGESSWGSGPGSRPTAVEGLALGSSASSSSEPPQIIINPARQKMVQKL
ALYEDGALDSLQLLSSSSLPGLGLEQDRQGPEESDEFQS
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| BDBM355852 |
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| n/a |
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| Name | BDBM355852 |
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| Synonyms: | US9815836, Compound 38 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H19N7O2 |
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| Mol. Mass. | 389.4106 |
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| SMILES | Cn1cc2NC(=O)c3cccc(n3)-c3cnn(CC#CCCCNC(=O)c2n1)c3 |
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| Structure | 
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