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TargetMucosa-associated lymphoid tissue lymphoma translocation protein 1
LigandBDBM355987
Substrate/Competitorn/a
Meas. Tech.Biochemical Assay
IC50 0.003±n/a nM
Citation Soldermann, CPQuancard, JSchlapbach, ASimic, OTintelnot-Blomley, MZoller, T Pyrazolo pyrimidine derivatives and their use as MALT1 inhibitors US Patent US9815842 Publication Date 11/14/2017
More Info.:Get all data from this article,  Assay Method
 
Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Name:Mucosa-associated lymphoid tissue lymphoma translocation protein 1
Synonyms:MALT lymphoma-associated translocation | MALT lymphoma-associated translocation (MALT1) | MALT1 | MALT1_HUMAN | MLT | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | Paracaspase
Type:Enzyme
Mol. Mass.:92257.81
Organism:Homo sapiens (Human)
Description:Q9UDY8
Residue:824
Sequence:
MSLLGDPLQALPPSAAPTGPLLAPPAGATLNRLREPLLRRLSELLDQAPEGRGWRRLAEL
AGSRGRLRLSCLDLEQCSLKVLEPEGSPSLCLLKLMGEKGCTVTELSDFLQAMEHTEVLQ
LLSPPGIKITVNPESKAVLAGQFVKLCCRATGHPFVQYQWFKMNKEIPNGNTSELIFNAV
HVKDAGFYVCRVNNNFTFEFSQWSQLDVCDIPESFQRSVDGVSESKLQICVEPTSQKLMP
GSTLVLQCVAVGSPIPHYQWFKNELPLTHETKKLYMVPYVDLEHQGTYWCHVYNDRDSQD
SKKVEIIIGRTDEAVECTEDELNNLGHPDNKEQTTDQPLAKDKVALLIGNMNYREHPKLK
APLVDVYELTNLLRQLDFKVVSLLDLTEYEMRNAVDEFLLLLDKGVYGLLYYAGHGYENF
GNSFMVPVDAPNPYRSENCLCVQNILKLMQEKETGLNVFLLDMCRKRNDYDDTIPILDAL
KVTANIVFGYATCQGAEAFEIQHSGLANGIFMKFLKDRLLEDKKITVLLDEVAEDMGKCH
LTKGKQALEIRSSLSEKRALTDPIQGTEYSAESLVRNLQWAKAHELPESMCLKFDCGVQI
QLGFAAEFSNVMIIYTSIVYKPPEIIMCDAYVTDFPLDLDIDPKDANKGTPEETGSYLVS
KDLPKHCLYTRLSSLQKLKEHLVFTVCLSYQYSGLEDTVEDKQEVNVGKPLIAKLDMHRG
LGRKTCFQTCLMSNGPYQSSAATSGGAGHYHSLQDPFHGVYHSHPGNPSNVTPADSCHCS
RTPDAFISSFAHHASCHFSRSNVPVETTDEIPFSFSDRLRISEK
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  Blast E-value cutoff:
BDBM355987
n/a
NameBDBM355987
Synonyms:(R)-1-(6-(2H-1,2,3- triazol-2-yl)-5- (trifluoromethyl)pyri- din-3-yl)-3-(2-chloro- 7-(1- methoxypropan-2- yl)pyrazolo[1,5- a]pyrimidin-6-yl)urea | US10442808, Example 111 | US9815842, Example 111
TypeSmall organic molecule
Emp. Form.C19H17ClF3N9O2
Mol. Mass.495.846
SMILESCOC[C@H](C)c1c(NC(=O)Nc2cnc(c(c2)C(F)(F)F)-n2nccn2)cnc2cc(Cl)nn12 |r|
Structure
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