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TargetMethionine aminopeptidase 2
LigandBDBM17411
Substrate/CompetitorBDBM17353
Meas. Tech.Enzyme Inhibition Assay
Ki 0.41±n/a nM
Citation Marino JPFisher PWHofmann GAKirkpatrick RBJanson CAJohnson RKMa CMattern MMeek TDRyan MDSchulz CSmith WWTew DGTomazek TAVeber DFXiong WCYamamoto YYamashita KYang GThompson SK Highly potent inhibitors of methionine aminopeptidase-2 based on a 1,2,4-triazole pharmacophore. J Med Chem 50:3777-85 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Methionine aminopeptidase 2
Name:Aminopeptidase
Synonyms:Initiation factor 2-associated 67 kDa glycoprotein | MAP 2 | MetAP 2 | Methionine aminopeptidase 2 (MetAP2) | Methionine aminopeptidases (HsMetAP2) | Peptidase M 2 | p67 | p67eIF2
Type:Enzyme
Mol. Mass.:52884.45
Organism:Homo sapiens (Human)
Description:n/a
Residue:478
Sequence:
MAGVEEVAASGSHLNGDLDPDDREEGAASTAEEAAKKKRRKKKKSKGPSAAGEQEPDKES
GASVDEVARQLERSALEDKERDEDDEDGDGDGDGATGKKKKKKKKKRGPKVQTDPPSVPI
CDLYPNGVFPKGQECEYPPTQDGRTAAWRTTSEEKKALDQASEEIWNDFREAAEAHRQVR
KYVMSWIKPGMTMIEICEKLEDCSRKLIKENGLNAGLAFPTGCSLNNCAAHYTPNAGDTT
VLQYDDICKIDFGTHISGRIIDCAFTVTFNPKYDTLLKAVKDATNTGIKCAGIDVRLCDV
GEAIQEVMESYEVEIDGKTYQVKPIRNLNGHSIGQYRIHAGKTVPIVKGGEATRMEEGEV
YAIETFGSTGKGVVHDDMECSHYMKNFDVGHVPIRLPRTKHLLNVINENFGTLAFCRRWL
DRLGESKYLMALKNLCDLGIVDPYPPLCDIKGSYTAQFEHTILLRPTCKEVVSRGDDY
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  Blast E-value cutoff:
BDBM17411
BDBM17353
NameBDBM17411
Synonyms:1,2,4-Triazole Compound, 69 | methyl 4-[(5-{[(2-fluorophenyl)methyl]sulfanyl}-4H-1,2,4-triazol-3-yl)amino]benzoate
TypeSmall organic molecule
Emp. Form.C17H15FN4O2S
Mol. Mass.358.39
SMILESCOC(=O)c1ccc(Nc2nnc(SCc3ccccc3F)[nH]2)cc1
Structure
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